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ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain.
Westling J, Fosang AJ, Last K, Thompson VP, Tomkinson KN, Hebert T, McDonagh T, Collins-Racie LA, LaVallie ER, Morris EA, Sandy JD. Westling J, et al. Among authors: tomkinson kn. J Biol Chem. 2002 May 3;277(18):16059-66. doi: 10.1074/jbc.M108607200. Epub 2002 Feb 19. J Biol Chem. 2002. PMID: 11854269 Free article.
Temporal associations between interleukin 22 and the extracellular domains of IL-22R and IL-10R2.
Li J, Tomkinson KN, Tan XY, Wu P, Yan G, Spaulding V, Deng B, Annis-Freeman B, Heveron K, Zollner R, De Zutter G, Wright JF, Crawford TK, Liu W, Jacobs KA, Wolfman NM, Ling V, Pittman DD, Veldman GM, Fouser LA. Li J, et al. Among authors: tomkinson kn. Int Immunopharmacol. 2004 May;4(5):693-708. doi: 10.1016/j.intimp.2004.01.010. Int Immunopharmacol. 2004. PMID: 15120653 Review.
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