Kazantsev A - Search Results

1

Arfaptin 2 regulates the aggregation of mutant huntingtin protein.

Peters PJ, Ning K, Palacios F, Boshans RL, Kazantsev A, Thompson LM, Woodman B, Bates GP, D'Souza-Schorey C. Peters PJ, et al. Among authors: kazantsev a. Nat Cell Biol. 2002 Mar;4(3):240-5. doi: 10.1038/ncb761. Nat Cell Biol. 2002. PMID: 11854752

2

A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila.

Kazantsev A, Walker HA, Slepko N, Bear JE, Preisinger E, Steffan JS, Zhu YZ, Gertler FB, Housman DE, Marsh JL, Thompson LM. Kazantsev A, et al. Nat Genet. 2002 Apr;30(4):367-76. doi: 10.1038/ng864. Epub 2002 Mar 25. Nat Genet. 2002. PMID: 11925563

3

Autophagy regulates the processing of amino terminal huntingtin fragments.

Qin ZH, Wang Y, Kegel KB, Kazantsev A, Apostol BL, Thompson LM, Yoder J, Aronin N, DiFiglia M. Qin ZH, et al. Among authors: kazantsev a. Hum Mol Genet. 2003 Dec 15;12(24):3231-44. doi: 10.1093/hmg/ddg346. Epub 2003 Oct 21. Hum Mol Genet. 2003. PMID: 14570716

4

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.

Steffan JS, Kazantsev A, Spasic-Boskovic O, Greenwald M, Zhu YZ, Gohler H, Wanker EE, Bates GP, Housman DE, Thompson LM. Steffan JS, et al. Among authors: kazantsev a. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6763-8. doi: 10.1073/pnas.100110097. Proc Natl Acad Sci U S A. 2000. PMID: 10823891 Free PMC article.

5

SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models.

Quinti L, Casale M, Moniot S, Pais TF, Van Kanegan MJ, Kaltenbach LS, Pallos J, Lim RG, Naidu SD, Runne H, Meisel L, Rauf NA, Leyfer D, Maxwell MM, Saiah E, Landers JE, Luthi-Carter R, Abagyan R, Dinkova-Kostova AT, Steegborn C, Marsh JL, Lo DC, Thompson LM, Kazantsev AG. Quinti L, et al. Cell Chem Biol. 2016 Jul 21;23(7):849-861. doi: 10.1016/j.chembiol.2016.05.015. Epub 2016 Jul 14. Cell Chem Biol. 2016. PMID: 27427231 Free article.

6

Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity.

Apostol BL, Illes K, Pallos J, Bodai L, Wu J, Strand A, Schweitzer ES, Olson JM, Kazantsev A, Marsh JL, Thompson LM. Apostol BL, et al. Among authors: kazantsev a. Hum Mol Genet. 2006 Jan 15;15(2):273-85. doi: 10.1093/hmg/ddi443. Epub 2005 Dec 5. Hum Mol Genet. 2006. PMID: 16330479

7

Antisense-mediated down-regulation of the human huntingtin gene.

Boado RJ, Kazantsev A, Apostol BL, Thompson LM, Pardridge WM. Boado RJ, et al. Among authors: kazantsev a. J Pharmacol Exp Ther. 2000 Oct;295(1):239-43. J Pharmacol Exp Ther. 2000. PMID: 10991985

8

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila.

Steffan JS, Bodai L, Pallos J, Poelman M, McCampbell A, Apostol BL, Kazantsev A, Schmidt E, Zhu YZ, Greenwald M, Kurokawa R, Housman DE, Jackson GR, Marsh JL, Thompson LM. Steffan JS, et al. Among authors: kazantsev a. Nature. 2001 Oct 18;413(6857):739-43. doi: 10.1038/35099568. Nature. 2001. PMID: 11607033

9

The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis.

Rockabrand E, Slepko N, Pantalone A, Nukala VN, Kazantsev A, Marsh JL, Sullivan PG, Steffan JS, Sensi SL, Thompson LM. Rockabrand E, et al. Among authors: kazantsev a. Hum Mol Genet. 2007 Jan 1;16(1):61-77. doi: 10.1093/hmg/ddl440. Epub 2006 Nov 29. Hum Mol Genet. 2007. PMID: 17135277

10

A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo.

Zhang X, Smith DL, Meriin AB, Engemann S, Russel DE, Roark M, Washington SL, Maxwell MM, Marsh JL, Thompson LM, Wanker EE, Young AB, Housman DE, Bates GP, Sherman MY, Kazantsev AG. Zhang X, et al. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):892-7. doi: 10.1073/pnas.0408936102. Epub 2005 Jan 10. Proc Natl Acad Sci U S A. 2005. PMID: 15642944 Free PMC article.

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