Rohr J - Search Results

1

Synthesis, pharmacokinetics, efficacy, and rat retinal toxicity of a novel mitomycin C-triamcinolone acetonide conjugate.

Macky TA, Oelkers C, Rix U, Heredia ML, Künzel E, Wimberly M, Rohrer B, Crosson CE, Rohr J. Macky TA, et al. Among authors: rohr j. J Med Chem. 2002 Feb 28;45(5):1122-7. doi: 10.1021/jm010511b. J Med Chem. 2002. PMID: 11855992

2

Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.

Remsing LL, Garcia-Bernardo J, Gonzalez A, Künzel E, Rix U, Braña AF, Bearden DW, Méndez C, Salas JA, Rohr J. Remsing LL, et al. Among authors: rohr j. J Am Chem Soc. 2002 Feb 27;124(8):1606-14. doi: 10.1021/ja0105156. J Am Chem Soc. 2002. PMID: 11853433 Free PMC article.

3

The structure of mithramycin reinvestigated.

Wohlert SE, Künzel E, Machinek R, Méndez C, Salas JA, Rohr J. Wohlert SE, et al. Among authors: rohr j. J Nat Prod. 1999 Jan;62(1):119-21. doi: 10.1021/np980355k. J Nat Prod. 1999. PMID: 9917296

4

Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycinone.

Zhu L, Ostash B, Rix U, Nur-E-Alam M, Mayers A, Luzhetskyy A, Mendez C, Salas JA, Bechthold A, Fedorenko V, Rohr J. Zhu L, et al. Among authors: rohr j. J Org Chem. 2005 Jan 21;70(2):631-8. doi: 10.1021/jo0483623. J Org Chem. 2005. PMID: 15651811 Free PMC article.

5

Urdamycin L: a novel metabolic shunt product that provides evidence for the role of the urdM gene in the urdamycin A biosynthetic pathway of Streptomyces fradiae TU 2717.

Rix U, Remsing LL, Hoffmeister D, Bechthold A, Rohr J. Rix U, et al. Among authors: rohr j. Chembiochem. 2003 Jan 3;4(1):109-11. doi: 10.1002/cbic.200390002. Chembiochem. 2003. PMID: 12512084 No abstract available.

6

Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.

Remsing LL, González AM, Nur-e-Alam M, Fernández-Lozano MJ, Braña AF, Rix U, Oliveira MA, Méndez C, Salas JA, Rohr J. Remsing LL, et al. Among authors: rohr j. J Am Chem Soc. 2003 May 14;125(19):5745-53. doi: 10.1021/ja034162h. J Am Chem Soc. 2003. PMID: 12733914 Free PMC article.

7

The dynamic structure of jadomycin B and the amino acid incorporation step of its biosynthesis.

Rix U, Zheng J, Remsing Rix LL, Greenwell L, Yang K, Rohr J. Rix U, et al. Among authors: rohr j. J Am Chem Soc. 2004 Apr 14;126(14):4496-7. doi: 10.1021/ja031724o. J Am Chem Soc. 2004. PMID: 15070349

8

Function of glycosyltransferase genes involved in urdamycin A biosynthesis.

Trefzer A, Hoffmeister D, Künzel E, Stockert S, Weitnauer G, Westrich L, Rix U, Fuchser J, Bindseil KU, Rohr J, Bechthold A. Trefzer A, et al. Among authors: rohr j. Chem Biol. 2000 Feb;7(2):133-42. doi: 10.1016/s1074-5521(00)00079-x. Chem Biol. 2000. PMID: 10662691

9

Functional analyses of oxygenases in jadomycin biosynthesis and identification of JadH as a bifunctional oxygenase/dehydrase.

Chen YH, Wang CC, Greenwell L, Rix U, Hoffmeister D, Vining LC, Rohr J, Yang KQ. Chen YH, et al. Among authors: rohr j. J Biol Chem. 2005 Jun 10;280(23):22508-14. doi: 10.1074/jbc.M414229200. Epub 2005 Apr 6. J Biol Chem. 2005. PMID: 15817470 Free PMC article.

10

Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.

Trefzer A, Blanco G, Remsing L, Künzel E, Rix U, Lipata F, Braña AF, Méndez C, Rohr J, Bechthold A, Salas JA. Trefzer A, et al. Among authors: rohr j. J Am Chem Soc. 2002 May 29;124(21):6056-62. doi: 10.1021/ja017385l. J Am Chem Soc. 2002. PMID: 12022840

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