Waszkowycz B - Search Results

1

PRO_SELECT: combining structure-based drug design and array-based chemistry for rapid lead discovery. 2. The development of a series of highly potent and selective factor Xa inhibitors.

Liebeschuetz JW, Jones SD, Morgan PJ, Murray CW, Rimmer AD, Roscoe JM, Waszkowycz B, Welsh PM, Wylie WA, Young SC, Martin H, Mahler J, Brady L, Wilkinson K. Liebeschuetz JW, et al. Among authors: waszkowycz b. J Med Chem. 2002 Mar 14;45(6):1221-32. doi: 10.1021/jm010944e. J Med Chem. 2002. PMID: 11881991

2

The design of phenylglycine containing benzamidine carboxamides as potent and selective inhibitors of factor Xa.

Jones SD, Liebeschuetz JW, Morgan PJ, Murray CW, Rimmer AD, Roscoe JM, Waszkowycz B, Welsh PM, Wylie WA, Young SC, Martin H, Mahler J, Brady L, Wilkinson K. Jones SD, et al. Among authors: waszkowycz b. Bioorg Med Chem Lett. 2001 Mar 12;11(5):733-6. doi: 10.1016/s0960-894x(01)00042-7. Bioorg Med Chem Lett. 2001. PMID: 11266180

3

PRO_LIGAND: an approach to de novo molecular design. 2. Design of novel molecules from molecular field analysis (MFA) models and pharmacophores.

Waszkowycz B, Clark DE, Frenkel D, Li J, Murray CW, Robson B, Westhead DR. Waszkowycz B, et al. J Med Chem. 1994 Nov 11;37(23):3994-4002. doi: 10.1021/jm00049a019. J Med Chem. 1994. PMID: 7966160

4

PRO_SELECT: combining structure-based drug design and combinatorial chemistry for rapid lead discovery. 1. Technology.

Murray CW, Clark DE, Auton TR, Firth MA, Li J, Sykes RA, Waszkowycz B, Westhead DR, Young SC. Murray CW, et al. Among authors: waszkowycz b. J Comput Aided Mol Des. 1997 Mar;11(2):193-207. doi: 10.1023/a:1008094712424. J Comput Aided Mol Des. 1997. PMID: 9089436

5

PRO_LIGAND: an approach to de novo molecular design. 4. Application to the design of peptides.

Frenkel D, Clark DE, Li J, Murray CW, RObson B, Waszkowycz B, Westhead DR. Frenkel D, et al. Among authors: waszkowycz b. J Comput Aided Mol Des. 1995 Jun;9(3):213-25. doi: 10.1007/BF00124453. J Comput Aided Mol Des. 1995. PMID: 7561974

6

PRO-LIGAND: an approach to de novo molecular design. 3. A genetic algorithm for structure refinement.

Westhead DR, Clark DE, Frenkel D, Li J, Murray CW, Robson B, Waszkowycz B. Westhead DR, et al. Among authors: waszkowycz b. J Comput Aided Mol Des. 1995 Apr;9(2):139-48. doi: 10.1007/BF00124404. J Comput Aided Mol Des. 1995. PMID: 7608745

7

PRO-LIGAND: an approach to de novo molecular design. 1. Application to the design of organic molecules.

Clark DE, Frenkel D, Levy SA, Li J, Murray CW, Robson B, Waszkowycz B, Westhead DR. Clark DE, et al. Among authors: waszkowycz b. J Comput Aided Mol Des. 1995 Feb;9(1):13-32. doi: 10.1007/BF00117275. J Comput Aided Mol Des. 1995. PMID: 7751867

8

The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity.

Newton R, Bowler KA, Burns EM, Chapman PJ, Fairweather EE, Fritzl SJR, Goldberg KM, Hamilton NM, Holt SV, Hopkins GV, Jones SD, Jordan AM, Lyons AJ, Nikki March H, McDonald NQ, Maguire LA, Mould DP, Purkiss AG, Small HF, Stowell AIJ, Thomson GJ, Waddell ID, Waszkowycz B, Watson AJ, Ogilvie DJ. Newton R, et al. Among authors: waszkowycz b. Eur J Med Chem. 2016 Apr 13;112:20-32. doi: 10.1016/j.ejmech.2016.01.039. Epub 2016 Jan 29. Eur J Med Chem. 2016. PMID: 26874741 Free PMC article.

9

Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.

Waszkowycz B, Smith KM, McGonagle AE, Jordan AM, Acton B, Fairweather EE, Griffiths LA, Hamilton NM, Hamilton NS, Hitchin JR, Hutton CP, James DI, Jones CD, Jones S, Mould DP, Small HF, Stowell AIJ, Tucker JA, Waddell ID, Ogilvie DJ. Waszkowycz B, et al. J Med Chem. 2018 Dec 13;61(23):10767-10792. doi: 10.1021/acs.jmedchem.8b01407. Epub 2018 Nov 19. J Med Chem. 2018. PMID: 30403352

10

Structure-based approaches to drug design and virtual screening.

Waszkowycz B. Waszkowycz B. Curr Opin Drug Discov Devel. 2002 May;5(3):407-13. Curr Opin Drug Discov Devel. 2002. PMID: 12058616 Review.

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