Scanlon I - Search Results

1

Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft models.

Friedlos F, Davies L, Scanlon I, Ogilvie LM, Martin J, Stribbling SM, Spooner RA, Niculescu-Duvaz I, Marais R, Springer CJ. Friedlos F, et al. Among authors: scanlon i. Cancer Res. 2002 Mar 15;62(6):1724-9. Cancer Res. 2002. PMID: 11912146

2

Novel fluorinated prodrugs for activation by carboxypeptidase G2 showing good in vivo antitumor activity in gene-directed enzyme prodrug therapy.

Davies LC, Friedlos F, Hedley D, Martin J, Ogilvie LM, Scanlon IJ, Springer CJ. Davies LC, et al. J Med Chem. 2005 Aug 11;48(16):5321-8. doi: 10.1021/jm0502182. J Med Chem. 2005. PMID: 16078849

3

Significant differences in biological parameters between prodrugs cleavable by carboxypeptidase G2 that generate 3,5-difluoro-phenol and -aniline nitrogen mustards in gene-directed enzyme prodrug therapy systems.

Niculescu-Duvaz I, Scanlon I, Niculescu-Duvaz D, Friedlos F, Martin J, Marais R, Springer CJ. Niculescu-Duvaz I, et al. Among authors: scanlon i. J Med Chem. 2004 May 6;47(10):2651-8. doi: 10.1021/jm030966w. J Med Chem. 2004. PMID: 15115406

4

Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2.

Schepelmann S, Hallenbeck P, Ogilvie LM, Hedley D, Friedlos F, Martin J, Scanlon I, Hay C, Hawkins LK, Marais R, Springer CJ. Schepelmann S, et al. Among authors: scanlon i. Cancer Res. 2005 Jun 15;65(12):5003-8. doi: 10.1158/0008-5472.CAN-05-0393. Cancer Res. 2005. PMID: 15958540

5

Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2.

Schepelmann S, Ogilvie LM, Hedley D, Friedlos F, Martin J, Scanlon I, Chen P, Marais R, Springer CJ. Schepelmann S, et al. Among authors: scanlon i. Cancer Res. 2007 May 15;67(10):4949-55. doi: 10.1158/0008-5472.CAN-07-0297. Cancer Res. 2007. PMID: 17510425 Free article.

6

Novel inhibitors of B-RAF based on a disubstituted pyrazine scaffold. Generation of a nanomolar lead.

Niculescu-Duvaz I, Roman E, Whittaker SR, Friedlos F, Kirk R, Scanlon IJ, Davies LC, Niculescu-Duvaz D, Marais R, Springer CJ. Niculescu-Duvaz I, et al. Among authors: scanlon ij. J Med Chem. 2006 Jan 12;49(1):407-16. doi: 10.1021/jm050983g. J Med Chem. 2006. PMID: 16392826

7

Gene regulation in cancer gene therapy strategies.

Scanlon I, Lehouritis P, Niculescu-Duvaz I, Marais R, Springer CJ. Scanlon I, et al. Curr Med Chem. 2003 Oct;10(20):2175-84. doi: 10.2174/0929867033456837. Curr Med Chem. 2003. PMID: 12871091 Review.

8

Novel inhibitors of the v-raf murine sarcoma viral oncogene homologue B1 (BRAF) based on a 2,6-disubstituted pyrazine scaffold.

Niculescu-Duvaz I, Roman E, Whittaker SR, Friedlos F, Kirk R, Scanlon IJ, Davies LC, Niculescu-Duvaz D, Marais R, Springer CJ. Niculescu-Duvaz I, et al. Among authors: scanlon ij. J Med Chem. 2008 Jun 12;51(11):3261-74. doi: 10.1021/jm070776b. Epub 2008 May 13. J Med Chem. 2008. PMID: 18473434

9

B-RAF is a therapeutic target in melanoma.

Karasarides M, Chiloeches A, Hayward R, Niculescu-Duvaz D, Scanlon I, Friedlos F, Ogilvie L, Hedley D, Martin J, Marshall CJ, Springer CJ, Marais R. Karasarides M, et al. Among authors: scanlon i. Oncogene. 2004 Aug 19;23(37):6292-8. doi: 10.1038/sj.onc.1207785. Oncogene. 2004. PMID: 15208680

10

Creating a next-generation phenotype library: the health data research UK Phenotype Library.

Thayer DS, Mumtaz S, Elmessary MA, Scanlon I, Zinnurov A, Coldea AI, Scanlon J, Chapman M, Curcin V, John A, DelPozo-Banos M, Davies H, Karwath A, Gkoutos GV, Fitzpatrick NK, Quint JK, Varma S, Milner C, Oliveira C, Parkinson H, Denaxas S, Hemingway H, Jefferson E. Thayer DS, et al. Among authors: scanlon i. JAMIA Open. 2024 Jun 17;7(2):ooae049. doi: 10.1093/jamiaopen/ooae049. eCollection 2024 Jul. JAMIA Open. 2024. PMID: 38895652 Free PMC article.

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