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Lys9 for Glu9 substitution in glucagon-like peptide-1(7-36)amide confers dipeptidylpeptidase IV resistance with cellular and metabolic actions similar to those of established antagonists glucagon-like peptide-1(9-36)amide and exendin (9-39).
Green BD, Mooney MH, Gault VA, Irwin N, Bailey CJ, Harriott P, Greer B, Flatt PR, O'Harte FP. Green BD, et al. Among authors: mooney mh. Metabolism. 2004 Feb;53(2):252-9. doi: 10.1016/j.metabol.2003.09.015. Metabolism. 2004. PMID: 14767880
Enhanced cAMP generation and insulin-releasing potency of two novel Tyr1-modified enzyme-resistant forms of glucose-dependent insulinotropic polypeptide is associated with significant antihyperglycaemic activity in spontaneous obesity-diabetes.
Gault VA, Flatt PR, Bailey CJ, Harriott P, Greer B, Mooney MH, O'harte FP. Gault VA, et al. Among authors: mooney mh. Biochem J. 2002 Nov 1;367(Pt 3):913-20. doi: 10.1042/BJ20020319. Biochem J. 2002. PMID: 12150711 Free PMC article.
60 results