Ramjeesingh M - Search Results

1

Studies of the molecular basis for cystic fibrosis using purified reconstituted CFTR protein.

Kogan I, Ramjeesingh M, Li C, Bear CE. Kogan I, et al. Among authors: ramjeesingh m. Methods Mol Med. 2002;70:143-57. doi: 10.1385/1-59259-187-6:143. Methods Mol Med. 2002. PMID: 11917519 No abstract available.

2

CFTR directly mediates nucleotide-regulated glutathione flux.

Kogan I, Ramjeesingh M, Li C, Kidd JF, Wang Y, Leslie EM, Cole SP, Bear CE. Kogan I, et al. Among authors: ramjeesingh m. EMBO J. 2003 May 1;22(9):1981-9. doi: 10.1093/emboj/cdg194. EMBO J. 2003. PMID: 12727866 Free PMC article.

3

Dimeric cystic fibrosis transmembrane conductance regulator exists in the plasma membrane.

Ramjeesingh M, Kidd JF, Huan LJ, Wang Y, Bear CE. Ramjeesingh M, et al. Biochem J. 2003 Sep 15;374(Pt 3):793-7. doi: 10.1042/BJ20030683. Biochem J. 2003. PMID: 12820897 Free PMC article.

4

Stable dimeric assembly of the second membrane-spanning domain of CFTR (cystic fibrosis transmembrane conductance regulator) reconstitutes a chloride-selective pore.

Ramjeesingh M, Ugwu F, Li C, Dhani S, Huan LJ, Wang Y, Bear CE. Ramjeesingh M, et al. Biochem J. 2003 Nov 1;375(Pt 3):633-41. doi: 10.1042/BJ20030774. Biochem J. 2003. PMID: 12892562 Free PMC article.

5

A heteromeric complex of the two nucleotide binding domains of cystic fibrosis transmembrane conductance regulator (CFTR) mediates ATPase activity.

Kidd JF, Ramjeesingh M, Stratford F, Huan LJ, Bear CE. Kidd JF, et al. Among authors: ramjeesingh m. J Biol Chem. 2004 Oct 1;279(40):41664-9. doi: 10.1074/jbc.M407666200. Epub 2004 Jul 28. J Biol Chem. 2004. PMID: 15284228 Free article.

6

ATPase assay of purified, reconstituted CFTR protein.

Kogan I, Ramjeesingh M, Bear CE. Kogan I, et al. Among authors: ramjeesingh m. J Cyst Fibros. 2004 Aug;3 Suppl 2:133-4. doi: 10.1016/j.jcf.2004.05.028. J Cyst Fibros. 2004. PMID: 15463945 Free article.

7

The intact CFTR protein mediates ATPase rather than adenylate kinase activity.

Ramjeesingh M, Ugwu F, Stratford FL, Huan LJ, Li C, Bear CE. Ramjeesingh M, et al. Biochem J. 2008 Jun 1;412(2):315-21. doi: 10.1042/BJ20071719. Biochem J. 2008. PMID: 18241200

8

Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease.

Pasyk S, Li C, Ramjeesingh M, Bear CE. Pasyk S, et al. Among authors: ramjeesingh m. Biochem J. 2009 Feb 15;418(1):185-90. doi: 10.1042/BJ20081424. Biochem J. 2009. PMID: 18945216 Free article.

9

A small-molecule modulator interacts directly with deltaPhe508-CFTR to modify its ATPase activity and conformational stability.

Wellhauser L, Kim Chiaw P, Pasyk S, Li C, Ramjeesingh M, Bear CE. Wellhauser L, et al. Among authors: ramjeesingh m. Mol Pharmacol. 2009 Jun;75(6):1430-8. doi: 10.1124/mol.109.055608. Epub 2009 Apr 1. Mol Pharmacol. 2009. PMID: 19339490

10

A chemical corrector modifies the channel function of F508del-CFTR.

Kim Chiaw P, Wellhauser L, Huan LJ, Ramjeesingh M, Bear CE. Kim Chiaw P, et al. Among authors: ramjeesingh m. Mol Pharmacol. 2010 Sep;78(3):411-8. doi: 10.1124/mol.110.065862. Epub 2010 May 25. Mol Pharmacol. 2010. PMID: 20501743

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