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New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease.
Kleymann G, Fischer R, Betz UA, Hendrix M, Bender W, Schneider U, Handke G, Eckenberg P, Hewlett G, Pevzner V, Baumeister J, Weber O, Henninger K, Keldenich J, Jensen A, Kolb J, Bach U, Popp A, Mäben J, Frappa I, Haebich D, Lockhoff O, Rübsamen-Waigmann H. Kleymann G, et al. Nat Med. 2002 Apr;8(4):392-8. doi: 10.1038/nm0402-392. Nat Med. 2002. PMID: 11927946
Other inhibitors of viral enzymes and functions.
Zimmermann H, Hewlett G, Rübsamen-Waigmann H. Zimmermann H, et al. Among authors: rubsamen waigmann h. Handb Exp Pharmacol. 2009;189(189):155-76. doi: 10.1007/978-3-540-79086-0_6. Handb Exp Pharmacol. 2009. PMID: 19048200 Free PMC article. Review.
Inhibition of hepatitis B virus replication by drug-induced depletion of nucleocapsids.
Deres K, Schröder CH, Paessens A, Goldmann S, Hacker HJ, Weber O, Krämer T, Niewöhner U, Pleiss U, Stoltefuss J, Graef E, Koletzki D, Masantschek RN, Reimann A, Jaeger R, Gross R, Beckermann B, Schlemmer KH, Haebich D, Rübsamen-Waigmann H. Deres K, et al. Science. 2003 Feb 7;299(5608):893-6. doi: 10.1126/science.1077215. Science. 2003. PMID: 12574631
Dihydroxythiophenes are novel potent inhibitors of human immunodeficiency virus integrase with a diketo acid-like pharmacophore.
Kehlenbeck S, Betz U, Birkmann A, Fast B, Göller AH, Henninger K, Lowinger T, Marrero D, Paessens A, Paulsen D, Pevzner V, Schohe-Loop R, Tsujishita H, Welker R, Kreuter J, Rübsamen-Waigmann H, Dittmer F. Kehlenbeck S, et al. Among authors: rubsamen waigmann h. J Virol. 2006 Jul;80(14):6883-94. doi: 10.1128/JVI.00306-06. J Virol. 2006. PMID: 16809294 Free PMC article.
111 results