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(3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assays showed a lack of toxicity of ganciclovir (GCV), C.OXTs, and their derivatives, to TaY(OK) cells at 1 microM. Therefore we compared the antiviral potencies of these drugs at 1 microM by monitoring the viral loads produced during a 1-day period during the course of the drug treatment. Among the drugs tested, 3'-fluorocarbocyclic oxetanocin A (3'F-C.OXT-A) was the most effective for inhibiting the virus production, and at concentrations ranging from 0.5 microM to 10 microM, the inhibition of the viral production was dose-dependent. A comparison of the chemical structures of the derivatives with that of C.OXT-A, which is the parental molecule, suggested that the 3'-fluorine-modification might account for the higher anti-HHV-6 activity and lower cytotoxicity.
Wang P, Abe K, Ojima T, Ohyashiki JH, Satoh H, Maruyama T, Nagata H, Tanaka H, Yamamoto K. Wang P, et al. Among authors: ojima t. Microbiol Immunol. 2001;45(6):457-66. doi: 10.1111/j.1348-0421.2001.tb02645.x. Microbiol Immunol. 2001. PMID: 11497221 Free article.
Cloning and sequence of a cDNA encoding Akazara scallop troponin C.
Ojima T, Tanaka H, Nishita K. Ojima T, et al. Arch Biochem Biophys. 1994 Jun;311(2):272-6. doi: 10.1006/abbi.1994.1237. Arch Biochem Biophys. 1994. PMID: 8203890
The amino acid sequence deduced from the cDNA showed 89% homology with that of Ezo-giant scallop (Patinopecten yessoensis) troponin C (K. Nishita, H. Tanaka, and T. Ojima, 1994, J. Biol. Chem. 269, 3464-3468). However, it showed lower homology with those of troponin …
The amino acid sequence deduced from the cDNA showed 89% homology with that of Ezo-giant scallop (Patinopecten yessoensis) troponin C (K. Ni …
643 results