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A synthetic uracil derivative with antitumor activity through decreasing cyclin D1 and Cdk1, and increasing p21 and p27 in MCF-7 cells.
Marchal JA, Núñez MC, Suárez I, Díaz-Gavilán M, Gómez-Vidal JA, Boulaiz H, Rodríguez-Serrano F, Gallo MA, Espinosa A, Aránega A, Campos JM. Marchal JA, et al. Among authors: nunez mc. Breast Cancer Res Treat. 2007 Nov;105(3):237-46. doi: 10.1007/s10549-006-9450-2. Epub 2006 Nov 24. Breast Cancer Res Treat. 2007. PMID: 17124554
Regiospecific microwave-assisted synthesis and cytotoxic activity against human breast cancer cells of (RS)-6-substituted-7- or 9-(2,3-dihydro-5H-1,4-benzodioxepin-3-yl)-7H- or -9H-purines.
Conejo-García A, Núñez MC, Marchal JA, Rodríguez-Serrano F, Aránega A, Gallo MA, Espinosa A, Campos JM. Conejo-García A, et al. Among authors: nunez mc. Eur J Med Chem. 2008 Aug;43(8):1742-8. doi: 10.1016/j.ejmech.2007.10.025. Epub 2007 Oct 25. Eur J Med Chem. 2008. PMID: 18069093
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