Smith EC - Search Results

1

Design and synthesis of a novel series of 1,2-disubstituted cyclopentanes as small, potent potentiators of 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid (AMPA) receptors.

Shepherd TA, Aikins JA, Bleakman D, Cantrell BE, Rearick JP, Simon RL, Smith EC, Stephenson GA, Zimmerman DM, Mandelzys A, Jarvie KR, Ho K, Deverill M, Kamboj RK. Shepherd TA, et al. Among authors: smith ec. J Med Chem. 2002 May 9;45(10):2101-11. doi: 10.1021/jm0105474. J Med Chem. 2002. PMID: 11985477

2

Structure-activity relationships of a series of 1-substituted-4-methylbenzimidazole neuropeptide Y-1 receptor antagonists.

Zimmerman DM, Cantrell BE, Smith EC, Nixon JA, Bruns RF, Gitter B, Hipskind PA, Ornstein PL, Zarrinmayeh H, Britton TC, Schober DA, Gehlert DR. Zimmerman DM, et al. Among authors: smith ec. Bioorg Med Chem Lett. 1998 Mar 3;8(5):473-6. doi: 10.1016/s0960-894x(98)00048-1. Bioorg Med Chem Lett. 1998. PMID: 9871601

3

Synthesis and excitatory amino acid pharmacology of a series of heterocyclic-fused quinoxalinones and quinazolinones.

McQuaid LA, Smith EC, South KK, Mitch CH, Schoepp DD, True RA, Calligaro DO, O'Malley PJ, Lodge D, Ornstein PL. McQuaid LA, et al. Among authors: smith ec. J Med Chem. 1992 Sep 4;35(18):3319-24. doi: 10.1021/jm00096a002. J Med Chem. 1992. PMID: 1382133

4

Carbocyclic[g]indole inhibitors of human nonpancreatic s-PLA2.

Sawyer JS, Beight DW, Smith EC, Snyder DW, Chastain MK, Tielking RL, Hartley LW, Carlson DG. Sawyer JS, et al. Among authors: smith ec. J Med Chem. 2005 Feb 10;48(3):893-6. doi: 10.1021/jm0401309. J Med Chem. 2005. PMID: 15689175

5

Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain.

Sawyer JS, Beight DW, Britt KS, Anderson BD, Campbell RM, Goodson T Jr, Herron DK, Li HY, McMillen WT, Mort N, Parsons S, Smith EC, Wagner JR, Yan L, Zhang F, Yingling JM. Sawyer JS, et al. Among authors: smith ec. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3581-4. doi: 10.1016/j.bmcl.2004.04.007. Bioorg Med Chem Lett. 2004. PMID: 15177479

6

Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain.

Sawyer JS, Anderson BD, Beight DW, Campbell RM, Jones ML, Herron DK, Lampe JW, McCowan JR, McMillen WT, Mort N, Parsons S, Smith EC, Vieth M, Weir LC, Yan L, Zhang F, Yingling JM. Sawyer JS, et al. Among authors: smith ec. J Med Chem. 2003 Sep 11;46(19):3953-6. doi: 10.1021/jm0205705. J Med Chem. 2003. PMID: 12954047

7

Synthesis and 5 alpha-reductase inhibitory activity of 8-substituted benzo[f]quinolinones derived from palladium mediated coupling reactions.

Smith EC, McQuaid LA, Goode RL, McNulty AM, Neubauer BL, Rocco VP, Audia JE. Smith EC, et al. Bioorg Med Chem Lett. 1998 Feb 17;8(4):395-8. doi: 10.1016/s0960-894x(98)00035-3. Bioorg Med Chem Lett. 1998. PMID: 9871692

8

3-Phenyl-4-hydroxyquinolin-2(1H)-ones: potent and selective antagonists at the strychnine-insensitive glycine site on the N-methyl-D-aspartate receptor complex.

McQuaid LA, Smith EC, Lodge D, Pralong E, Wikel JH, Calligaro DO, O'Malley PJ. McQuaid LA, et al. Among authors: smith ec. J Med Chem. 1992 Sep 4;35(18):3423-5. doi: 10.1021/jm00096a019. J Med Chem. 1992. PMID: 1326635 No abstract available.

9

Synthesis and biological activity of structural analogues of the anticancer benzophenanthridine alkaloid nitidine chloride.

Cushman M, Mohan P, Smith EC. Cushman M, et al. Among authors: smith ec. J Med Chem. 1984 Apr;27(4):544-7. doi: 10.1021/jm00370a021. J Med Chem. 1984. PMID: 6708057

10

2-Amino- and 2-guanidino-1,2,3,4-tetrahydro-1,4-epoxynaphthalenes as conformationally defined analogues of alpha-adrenergic agents.

Smith EC, Riley TN, Borne RF, Waters IW. Smith EC, et al. J Med Chem. 1987 Jun;30(6):1105-10. doi: 10.1021/jm00389a023. J Med Chem. 1987. PMID: 2884315

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