Geoghegan KF - Search Results

1

Synthesis and biological activity of selective pipecolic acid-based TNF-alpha converting enzyme (TACE) inhibitors.

Letavic MA, Axt MZ, Barberia JT, Carty TJ, Danley DE, Geoghegan KF, Halim NS, Hoth LR, Kamath AV, Laird ER, Lopresti-Morrow LL, McClure KF, Mitchell PG, Natarajan V, Noe MC, Pandit J, Reeves L, Schulte GK, Snow SL, Sweeney FJ, Tan DH, Yu CH. Letavic MA, et al. Among authors: geoghegan kf. Bioorg Med Chem Lett. 2002 May 20;12(10):1387-90. doi: 10.1016/s0960-894x(02)00183-x. Bioorg Med Chem Lett. 2002. PMID: 11992783

2

Expression and protein chemistry yielding crystallization of the catalytic domain of ADAM17 complexed with a hydroxamate inhibitor.

Hoth LR, Tan DH, Wang IK, Wengender PA, Thompson MA, Kamath AV, Geoghegan KF. Hoth LR, et al. Among authors: geoghegan kf. Protein Expr Purif. 2007 Apr;52(2):313-9. doi: 10.1016/j.pep.2006.10.021. Epub 2006 Nov 7. Protein Expr Purif. 2007. PMID: 17169570

3

Cyclization of N-terminal S-carbamoylmethylcysteine causing loss of 17 Da from peptides and extra peaks in peptide maps.

Geoghegan KF, Hoth LR, Tan DH, Borzilleri KA, Withka JM, Boyd JG. Geoghegan KF, et al. J Proteome Res. 2002 Mar-Apr;1(2):181-7. doi: 10.1021/pr025503d. J Proteome Res. 2002. PMID: 12643538

4

The 2.0 A crystal structure of the ERalpha ligand-binding domain complexed with lasofoxifene.

Vajdos FF, Hoth LR, Geoghegan KF, Simons SP, LeMotte PK, Danley DE, Ammirati MJ, Pandit J. Vajdos FF, et al. Among authors: geoghegan kf. Protein Sci. 2007 May;16(5):897-905. doi: 10.1110/ps.062729207. Protein Sci. 2007. PMID: 17456742 Free PMC article.

5

Biophysical and biochemical approach to locating an inhibitor binding site on cholesteryl ester transfer protein.

Cunningham D, Lin W, Hoth LR, Danley DE, Ruggeri RB, Geoghegan KF, Chrunyk BA, Boyd JG. Cunningham D, et al. Among authors: geoghegan kf. Bioconjug Chem. 2008 Aug;19(8):1604-13. doi: 10.1021/bc800165n. Epub 2008 Jul 23. Bioconjug Chem. 2008. PMID: 18646836

6

Chemical and biochemical issues related to X-ray crystallography of the ligand-binding domain of estrogen receptor alpha.

Goldstein SW, Bordner J, Hoth LR, Geoghegan KF. Goldstein SW, et al. Among authors: geoghegan kf. Bioconjug Chem. 2001 May-Jun;12(3):406-13. doi: 10.1021/bc000127d. Bioconjug Chem. 2001. PMID: 11353539

7

Structure and mechanism of formation of recombinant-derived chymosin C.

Danley DE, Geoghegan KF. Danley DE, et al. Among authors: geoghegan kf. J Biol Chem. 1988 Jul 15;263(20):9785-9. J Biol Chem. 1988. PMID: 3133368 Free article.

8

Dye-pair reporter systems for protein-peptide molecular interactions.

Geoghegan KF, Rosner PJ, Hoth LR. Geoghegan KF, et al. Bioconjug Chem. 2000 Jan-Feb;11(1):71-7. doi: 10.1021/bc9900845. Bioconjug Chem. 2000. PMID: 10639088

9

IL-1 beta maturation: evidence that mature cytokine formation can be induced specifically by nigericin.

Perregaux D, Barberia J, Lanzetti AJ, Geoghegan KF, Carty TJ, Gabel CA. Perregaux D, et al. Among authors: geoghegan kf. J Immunol. 1992 Aug 15;149(4):1294-303. J Immunol. 1992. PMID: 1500719

10

Glutathione s-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1beta posttranslational processing.

Laliberte RE, Perregaux DG, Hoth LR, Rosner PJ, Jordan CK, Peese KM, Eggler JF, Dombroski MA, Geoghegan KF, Gabel CA. Laliberte RE, et al. Among authors: geoghegan kf. J Biol Chem. 2003 May 9;278(19):16567-78. doi: 10.1074/jbc.M211596200. Epub 2003 Mar 6. J Biol Chem. 2003. PMID: 12624100 Free article.

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