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Page 1
Substituted 4-(2,2-diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters.
Frenette R, Blouin M, Brideau C, Chauret N, Ducharme Y, Friesen RW, Hamel P, Jones TR, Laliberté F, Li C, Masson P, McAuliffe M, Girard Y. Frenette R, et al. Among authors: ducharme y. Bioorg Med Chem Lett. 2002 Oct 21;12(20):3009-13. doi: 10.1016/s0960-894x(02)00615-7. Bioorg Med Chem Lett. 2002. PMID: 12270195
Substituted aminopyridines as potent and selective phosphodiesterase-4 inhibitors.
Côté B, Frenette R, Prescott S, Blouin M, Brideau C, Ducharme Y, Friesen RW, Laliberté F, Masson P, Styhler A, Girard Y. Côté B, et al. Among authors: ducharme y. Bioorg Med Chem Lett. 2003 Feb 24;13(4):741-4. doi: 10.1016/s0960-894x(02)01030-2. Bioorg Med Chem Lett. 2003. PMID: 12639571
Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity.
Friesen RW, Ducharme Y, Ball RG, Blouin M, Boulet L, Côté B, Frenette R, Girard M, Guay D, Huang Z, Jones TR, Laliberté F, Lynch JJ, Mancini J, Martins E, Masson P, Muise E, Pon DJ, Siegl PK, Styhler A, Tsou NN, Turner MJ, Young RN, Girard Y. Friesen RW, et al. Among authors: ducharme y. J Med Chem. 2003 Jun 5;46(12):2413-26. doi: 10.1021/jm0204542. J Med Chem. 2003. PMID: 12773045
Substituted coumarins as potent 5-lipoxygenase inhibitors.
Grimm EL, Brideau C, Chauret N, Chan CC, Delorme D, Ducharme Y, Ethier D, Falgueyret JP, Friesen RW, Guay J, Hamel P, Riendeau D, Soucy-Breau C, Tagari P, Girard Y. Grimm EL, et al. Among authors: ducharme y. Bioorg Med Chem Lett. 2006 May 1;16(9):2528-31. doi: 10.1016/j.bmcl.2006.01.085. Epub 2006 Feb 7. Bioorg Med Chem Lett. 2006. PMID: 16464579
Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors.
Côté B, Boulet L, Brideau C, Claveau D, Ethier D, Frenette R, Gagnon M, Giroux A, Guay J, Guiral S, Mancini J, Martins E, Massé F, Méthot N, Riendeau D, Rubin J, Xu D, Yu H, Ducharme Y, Friesen RW. Côté B, et al. Among authors: ducharme y. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6816-20. doi: 10.1016/j.bmcl.2007.10.033. Epub 2007 Oct 17. Bioorg Med Chem Lett. 2007. PMID: 18029174
Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors.
Giroux A, Boulet L, Brideau C, Chau A, Claveau D, Côté B, Ethier D, Frenette R, Gagnon M, Guay J, Guiral S, Mancini J, Martins E, Massé F, Méthot N, Riendeau D, Rubin J, Xu D, Yu H, Ducharme Y, Friesen RW. Giroux A, et al. Among authors: ducharme y. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5837-41. doi: 10.1016/j.bmcl.2009.08.085. Epub 2009 Aug 28. Bioorg Med Chem Lett. 2009. PMID: 19748780
Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: structure-activity relationship study directed toward the improvement of metabolic stability.
Delorme D, Ducharme Y, Brideau C, Chan CC, Chauret N, Desmarais S, Dubé D, Falgueyret JP, Fortin R, Guay J, Hamel P, Jones TR, Lépine C, Li C, McAuliffe M, McFarlane CS, Nicoll-Griffith DA, Riendeau D, Yergey JA, Girard Y. Delorme D, et al. Among authors: ducharme y. J Med Chem. 1996 Sep 27;39(20):3951-70. doi: 10.1021/jm960301c. J Med Chem. 1996. PMID: 8831761
34 results