Silva J - Search Results

1

Discovery of L-791,943: a potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor.

Guay D, Hamel P, Blouin M, Brideau C, Chan CC, Chauret N, Ducharme Y, Huang Z, Girard M, Jones TR, Laliberté F, Masson P, McAuliffe M, Piechuta H, Silva J, Young RN, Girard Y. Guay D, et al. Among authors: silva j. Bioorg Med Chem Lett. 2002 Jun 3;12(11):1457-61. doi: 10.1016/s0960-894x(02)00190-7. Bioorg Med Chem Lett. 2002. PMID: 12031319

2

Improving metabolic stability of phosphodiesterase-4 inhibitors containing a substituted catechol: prevention of reactive intermediate formation and covalent binding.

Chauret N, Guay D, Li C, Day S, Silva J, Blouin M, Ducharme Y, Yergey JA, Nicoll-Griffith DA. Chauret N, et al. Among authors: silva j. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2149-52. doi: 10.1016/s0960-894x(02)00349-9. Bioorg Med Chem Lett. 2002. PMID: 12127525

3

Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524).

Sturino CF, O'Neill G, Lachance N, Boyd M, Berthelette C, Labelle M, Li L, Roy B, Scheigetz J, Tsou N, Aubin Y, Bateman KP, Chauret N, Day SH, Lévesque JF, Seto C, Silva JH, Trimble LA, Carriere MC, Denis D, Greig G, Kargman S, Lamontagne S, Mathieu MC, Sawyer N, Slipetz D, Abraham WM, Jones T, McAuliffe M, Piechuta H, Nicoll-Griffith DA, Wang Z, Zamboni R, Young RN, Metters KM. Sturino CF, et al. Among authors: silva jh. J Med Chem. 2007 Feb 22;50(4):794-806. doi: 10.1021/jm0603668. J Med Chem. 2007. PMID: 17300164

4

Interspecies in vitro metabolism of the phosphodiesterase-4 (PDE4) inhibitor L-454,560.

Bateman KP, Trimble L, Chauret N, Silva J, Day S, Macdonald D, Dube D, Gallant M, Mastracchio A, Perrier H, Girard Y, Nicoll-Griffith D. Bateman KP, et al. Among authors: silva j. J Mass Spectrom. 2006 Jun;41(6):771-80. doi: 10.1002/jms.1033. J Mass Spectrom. 2006. PMID: 16705670

5

In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663).

Chauret N, Yergey JA, Brideau C, Friesen RW, Mancini J, Riendeau D, Silva J, Styhler A, Trimble LA, Nicoll-Griffith DA. Chauret N, et al. Among authors: silva j. Bioorg Med Chem Lett. 2001 Apr 23;11(8):1059-62. doi: 10.1016/s0960-894x(01)00135-4. Bioorg Med Chem Lett. 2001. PMID: 11327589

6

In vitro metabolism of the COX-2 inhibitor DFU, including a novel glutathione adduct rearomatization.

Yergey JA, Trimble LA, Silva J, Chauret N, Li C, Therien M, Grimm E, Nicoll-Griffith DA. Yergey JA, et al. Among authors: silva j. Drug Metab Dispos. 2001 May;29(5):638-44. Drug Metab Dispos. 2001. PMID: 11302928

7

Exploring the Potential Use of Probiotics, Prebiotics, Synbiotics, and Postbiotics as Adjuvants for Modulating the Vaginal Microbiome: a Bibliometric Review.

Xavier-Santos D, Bedani R, de Almeida Vieira I, Padilha M, Lima CMG, Silva JDR, Ferreira BM, Giraldo PC, Pagnossa JP, Sivieri K, Antunes AEC, Sant'Ana AS. Xavier-Santos D, et al. Among authors: silva jdr. Probiotics Antimicrob Proteins. 2025 Jan 17. doi: 10.1007/s12602-024-10444-8. Online ahead of print. Probiotics Antimicrob Proteins. 2025. PMID: 39821884 Review.

8

Structure of the Kaposi's sarcoma-associated herpesvirus gB in post-fusion conformation.

Ito F, Zhen J, Xie G, Huang H, Silva JC, Wu T-T, Zhou ZH. Ito F, et al. Among authors: silva jc. J Virol. 2025 Jan 17:e0153324. doi: 10.1128/jvi.01533-24. Online ahead of print. J Virol. 2025. PMID: 39818969

9

Microprolactinoma Growth During Pregnancy With Pituitary Tumor Apoplexy: Case Report and Review of the Literature.

Introini L, Silva J, Risso M, Mendoza B, Pineyro MM. Introini L, et al. Among authors: silva j. Case Rep Endocrinol. 2025 Jan 7;2025:2490132. doi: 10.1155/crie/2490132. eCollection 2025. Case Rep Endocrinol. 2025. PMID: 39816925 Free PMC article.

10

Soilscapes from Byers Peninsula, Maritime Antarctic: landform-lithology controls in soil formation.

Silva JPD, Francelino MR, Faria ALL, Palma HP, Oliveira IA, Souza JJLL, Schaefer CEGR. Silva JPD, et al. An Acad Bras Cienc. 2025 Jan 13;96(suppl 2):e20240583. doi: 10.1590/0001-3765202420240583. eCollection 2025. An Acad Bras Cienc. 2025. PMID: 39813481 Free article.

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