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Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies.
Neumann M, Kahle PJ, Giasson BI, Ozmen L, Borroni E, Spooren W, Müller V, Odoy S, Fujiwara H, Hasegawa M, Iwatsubo T, Trojanowski JQ, Kretzschmar HA, Haass C. Neumann M, et al. Among authors: iwatsubo t. J Clin Invest. 2002 Nov;110(10):1429-39. doi: 10.1172/JCI15777. J Clin Invest. 2002. PMID: 12438441 Free PMC article.
Ubiquitination of alpha-synuclein.
Nonaka T, Iwatsubo T, Hasegawa M. Nonaka T, et al. Among authors: iwatsubo t. Biochemistry. 2005 Jan 11;44(1):361-8. doi: 10.1021/bi0485528. Biochemistry. 2005. PMID: 15628878
alpha-Synuclein is phosphorylated in synucleinopathy lesions.
Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, Shen J, Takio K, Iwatsubo T. Fujiwara H, et al. Among authors: iwatsubo t. Nat Cell Biol. 2002 Feb;4(2):160-4. doi: 10.1038/ncb748. Nat Cell Biol. 2002. PMID: 11813001
Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions.
Hasegawa M, Fujiwara H, Nonaka T, Wakabayashi K, Takahashi H, Lee VM, Trojanowski JQ, Mann D, Iwatsubo T. Hasegawa M, et al. Among authors: iwatsubo t. J Biol Chem. 2002 Dec 13;277(50):49071-6. doi: 10.1074/jbc.M208046200. Epub 2002 Oct 10. J Biol Chem. 2002. PMID: 12377775 Free article.
We have shown previously (Fujiwara, H., Hasegawa, M., Dohmae, N., Kawashima, A., Masliah, E., Goldberg, M. S., Shen, J., Takio, K., and Iwatsubo, T. (2002) Nat. Cell Biol. 4, 160-164) that alpha-synuclein deposited in synucleinopathy brains is extensively phosphoryl …
We have shown previously (Fujiwara, H., Hasegawa, M., Dohmae, N., Kawashima, A., Masliah, E., Goldberg, M. S., Shen, J., Takio, K., and I …
622 results