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Discovery of potent, nonsteroidal, and highly selective glucocorticoid receptor antagonists.
J Med Chem. 2002 Jun 6;45(12):2417-24. doi: 10.1021/jm0105530.
J Med Chem. 2002.
PMID: 12036351
Placement of alkyl substituents on the C-7 piperazine ring of fluoroquinolones: dramatic differential effects on mammalian topoisomerase II and DNA gyrase.
Gootz TD, McGuirk PR, Moynihan MS, Haskell SL.
Gootz TD, et al. Among authors: moynihan ms.
Antimicrob Agents Chemother. 1994 Jan;38(1):130-3. doi: 10.1128/AAC.38.1.130.
Antimicrob Agents Chemother. 1994.
PMID: 8141566
Free PMC article.
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Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential.
Elsea SH, McGuirk PR, Gootz TD, Moynihan M, Osheroff N.
Elsea SH, et al.
Antimicrob Agents Chemother. 1993 Oct;37(10):2179-86. doi: 10.1128/AAC.37.10.2179.
Antimicrob Agents Chemother. 1993.
PMID: 8257142
Free PMC article.
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Effects of quinolone derivatives on eukaryotic topoisomerase II. A novel mechanism for enhancement of enzyme-mediated DNA cleavage.
Robinson MJ, Martin BA, Gootz TD, McGuirk PR, Moynihan M, Sutcliffe JA, Osheroff N.
Robinson MJ, et al.
J Biol Chem. 1991 Aug 5;266(22):14585-92.
J Biol Chem. 1991.
PMID: 1650363
Free article.
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