Helfand MS - Search Results

1

Development of a sensitive and specific enzyme-linked immunosorbent assay for detecting and quantifying CMY-2 and SHV beta-lactamases.

Hujer AM, Page MG, Helfand MS, Yeiser B, Bonomo RA. Hujer AM, et al. Among authors: helfand ms. J Clin Microbiol. 2002 Jun;40(6):1947-57. doi: 10.1128/JCM.40.6.1947-1957.2002. J Clin Microbiol. 2002. PMID: 12037047 Free PMC article.

2

Unexpected advanced generation cephalosporinase activity of the M69F variant of SHV beta-lactamase.

Helfand MS, Hujer AM, Sönnichsen FD, Bonomo RA. Helfand MS, et al. J Biol Chem. 2002 Dec 6;277(49):47719-23. doi: 10.1074/jbc.M207271200. Epub 2002 Sep 26. J Biol Chem. 2002. PMID: 12354765 Free article.

3

Amino acid substitutions at Ambler position Gly238 in the SHV-1 beta-lactamase: exploring sequence requirements for resistance to penicillins and cephalosporins.

Hujer AM, Hujer KM, Helfand MS, Anderson VE, Bonomo RA. Hujer AM, et al. Among authors: helfand ms. Antimicrob Agents Chemother. 2002 Dec;46(12):3971-7. doi: 10.1128/AAC.46.12.3971-3977.2002. Antimicrob Agents Chemother. 2002. PMID: 12435703 Free PMC article.

4

Beta-lactamases: a survey of protein diversity.

Helfand MS, Bonomo RA. Helfand MS, et al. Curr Drug Targets Infect Disord. 2003 Mar;3(1):9-23. doi: 10.2174/1568005033342181. Curr Drug Targets Infect Disord. 2003. PMID: 12570729 Review.

5

Understanding resistance to beta-lactams and beta-lactamase inhibitors in the SHV beta-lactamase: lessons from the mutagenesis of SER-130.

Helfand MS, Bethel CR, Hujer AM, Hujer KM, Anderson VE, Bonomo RA. Helfand MS, et al. J Biol Chem. 2003 Dec 26;278(52):52724-9. doi: 10.1074/jbc.M306059200. Epub 2003 Oct 8. J Biol Chem. 2003. PMID: 14534312 Free article.

6

Exploring the effectiveness of tazobactam against ceftazidime resistant Escherichia coli: insights from the comparison between susceptibility testing and beta-lactamase inhibition.

Bethel CR, Hujer AM, Helfand MS, Bonomo RA. Bethel CR, et al. Among authors: helfand ms. FEMS Microbiol Lett. 2004 May 1;234(1):99-103. doi: 10.1016/j.femsle.2004.03.025. FEMS Microbiol Lett. 2004. PMID: 15109726

7

Current challenges in antimicrobial chemotherapy: the impact of extended-spectrum beta-lactamases and metallo-beta-lactamases on the treatment of resistant Gram-negative pathogens.

Helfand MS, Bonomo RA. Helfand MS, et al. Curr Opin Pharmacol. 2005 Oct;5(5):452-8. doi: 10.1016/j.coph.2005.04.013. Curr Opin Pharmacol. 2005. PMID: 16084766 Review.

8

Role of Asp104 in the SHV beta-lactamase.

Bethel CR, Hujer AM, Hujer KM, Thomson JM, Ruszczycky MW, Anderson VE, Pusztai-Carey M, Taracila M, Helfand MS, Bonomo RA. Bethel CR, et al. Among authors: helfand ms. Antimicrob Agents Chemother. 2006 Dec;50(12):4124-31. doi: 10.1128/AAC.00848-06. Epub 2006 Sep 18. Antimicrob Agents Chemother. 2006. PMID: 16982784 Free PMC article.

9

Following the reactions of mechanism-based inhibitors with beta-lactamase by Raman crystallography.

Helfand MS, Totir MA, Carey MP, Hujer AM, Bonomo RA, Carey PR. Helfand MS, et al. Biochemistry. 2003 Nov 25;42(46):13386-92. doi: 10.1021/bi035716w. Biochemistry. 2003. PMID: 14621983

10

Tazobactam forms a stoichiometric trans-enamine intermediate in the E166A variant of SHV-1 beta-lactamase: 1.63 A crystal structure.

Padayatti PS, Helfand MS, Totir MA, Carey MP, Hujer AM, Carey PR, Bonomo RA, van den Akker F. Padayatti PS, et al. Among authors: helfand ms. Biochemistry. 2004 Feb 3;43(4):843-8. doi: 10.1021/bi035985m. Biochemistry. 2004. PMID: 14744126

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