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Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.
Hewitson KS, McNeill LA, Riordan MV, Tian YM, Bullock AN, Welford RW, Elkins JM, Oldham NJ, Bhattacharya S, Gleadle JM, Ratcliffe PJ, Pugh CW, Schofield CJ. Hewitson KS, et al. J Biol Chem. 2002 Jul 19;277(29):26351-5. doi: 10.1074/jbc.C200273200. Epub 2002 May 31. J Biol Chem. 2002. PMID: 12042299 Free article.
The HIF pathway as a therapeutic target.
Hewitson KS, Schofield CJ. Hewitson KS, et al. Drug Discov Today. 2004 Aug 15;9(16):704-11. doi: 10.1016/S1359-6446(04)03202-7. Drug Discov Today. 2004. PMID: 15341784 Review.
Selective inhibition of factor inhibiting hypoxia-inducible factor.
McDonough MA, McNeill LA, Tilliet M, Papamicaël CA, Chen QY, Banerji B, Hewitson KS, Schofield CJ. McDonough MA, et al. Among authors: hewitson ks. J Am Chem Soc. 2005 Jun 1;127(21):7680-1. doi: 10.1021/ja050841b. J Am Chem Soc. 2005. PMID: 15913349
Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).
Cockman ME, Lancaster DE, Stolze IP, Hewitson KS, McDonough MA, Coleman ML, Coles CH, Yu X, Hay RT, Ley SC, Pugh CW, Oldham NJ, Masson N, Schofield CJ, Ratcliffe PJ. Cockman ME, et al. Among authors: hewitson ks. Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14767-72. doi: 10.1073/pnas.0606877103. Epub 2006 Sep 26. Proc Natl Acad Sci U S A. 2006. PMID: 17003112 Free PMC article.
47 results