Wick MJ - Search Results

1

Cloning and characterization of a testis and brain-specific isoform of mouse 3'-phosphoinositide-dependent protein kinase-1, mPDK-1 beta.

Dong LQ, Ramos FJ, Wick MJ, Lim MA, Guo Z, Strong R, Richardson A, Liu F. Dong LQ, et al. Among authors: wick mj. Biochem Biophys Res Commun. 2002 May 31;294(1):136-44. doi: 10.1016/S0006-291X(02)00449-7. Biochem Biophys Res Commun. 2002. PMID: 12054753

2

Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton.

Dong LQ, Landa LR, Wick MJ, Zhu L, Mukai H, Ono Y, Liu F. Dong LQ, et al. Among authors: wick mj. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5089-94. doi: 10.1073/pnas.090491897. Proc Natl Acad Sci U S A. 2000. PMID: 10792047 Free PMC article.

3

Mechanism of phosphorylation of protein kinase B/Akt by a constitutively active 3-phosphoinositide-dependent protein kinase-1.

Wick MJ, Dong LQ, Riojas RA, Ramos FJ, Liu F. Wick MJ, et al. J Biol Chem. 2000 Dec 22;275(51):40400-6. doi: 10.1074/jbc.M003937200. J Biol Chem. 2000. PMID: 11006271 Free article.

4

Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt.

Wick MJ, Dong LQ, Hu D, Langlais P, Liu F. Wick MJ, et al. J Biol Chem. 2001 Nov 16;276(46):42843-50. doi: 10.1074/jbc.M102116200. Epub 2001 Sep 10. J Biol Chem. 2001. PMID: 11551902 Free article.

5

Substitution of the autophosphorylation site Thr516 with a negatively charged residue confers constitutive activity to mouse 3-phosphoinositide-dependent protein kinase-1 in cells.

Wick MJ, Wick KR, Chen H, He H, Dong LQ, Quon MJ, Liu F. Wick MJ, et al. Among authors: wick kr. J Biol Chem. 2002 May 10;277(19):16632-8. doi: 10.1074/jbc.M112402200. Epub 2002 Feb 27. J Biol Chem. 2002. PMID: 11877406 Free article.

6

Mouse 3-phosphoinositide-dependent protein kinase-1 undergoes dimerization and trans-phosphorylation in the activation loop.

Wick MJ, Ramos FJ, Chen H, Quon MJ, Dong LQ, Liu F. Wick MJ, et al. J Biol Chem. 2003 Oct 31;278(44):42913-9. doi: 10.1074/jbc.M304172200. Epub 2003 Aug 14. J Biol Chem. 2003. PMID: 12923190 Free article.

7

Nuclear translocation of 3'-phosphoinositide-dependent protein kinase 1 (PDK-1): a potential regulatory mechanism for PDK-1 function.

Lim MA, Kikani CK, Wick MJ, Dong LQ. Lim MA, et al. Among authors: wick mj. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14006-11. doi: 10.1073/pnas.2335486100. Epub 2003 Nov 17. Proc Natl Acad Sci U S A. 2003. PMID: 14623982 Free PMC article.

8

The clinical effect of the dual-targeting strategy involving PI3K/AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancer.

Shimizu T, Tolcher AW, Papadopoulos KP, Beeram M, Rasco DW, Smith LS, Gunn S, Smetzer L, Mays TA, Kaiser B, Wick MJ, Alvarez C, Cavazos A, Mangold GL, Patnaik A. Shimizu T, et al. Among authors: wick mj. Clin Cancer Res. 2012 Apr 15;18(8):2316-25. doi: 10.1158/1078-0432.CCR-11-2381. Epub 2012 Jan 19. Clin Cancer Res. 2012. PMID: 22261800

9

Targeting MDM2 for Treatment of Adenoid Cystic Carcinoma.

Warner KA, Nör F, Acasigua GA, Martins MD, Zhang Z, McLean SA, Spector ME, Chepeha DB, Helman J, Wick MJ, Moskaluk CA, Castilho RM, Pearson AT, Wang S, Nör JE. Warner KA, et al. Among authors: wick mj. Clin Cancer Res. 2016 Jul 15;22(14):3550-9. doi: 10.1158/1078-0432.CCR-15-1698. Epub 2016 Mar 2. Clin Cancer Res. 2016. PMID: 26936915 Free PMC article.

10

Targeting the Oncogenic Transcriptional Regulator MYB in Adenoid Cystic Carcinoma by Inhibition of IGF1R/AKT Signaling.

Andersson MK, Afshari MK, Andrén Y, Wick MJ, Stenman G. Andersson MK, et al. Among authors: wick mj. J Natl Cancer Inst. 2017 Sep 1;109(9). doi: 10.1093/jnci/djx017. J Natl Cancer Inst. 2017. PMID: 28954282

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