Wilson IA - Search Results

1

10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway.

Marsilje TH, Labroli MA, Hedrick MP, Jin Q, Desharnais J, Baker SJ, Gooljarsingh LT, Ramcharan J, Tavassoli A, Zhang Y, Wilson IA, Beardsley GP, Benkovic SJ, Boger DL. Marsilje TH, et al. Among authors: wilson ia. Bioorg Med Chem. 2002 Aug;10(8):2739-49. doi: 10.1016/s0968-0896(02)00102-5. Bioorg Med Chem. 2002. PMID: 12057663

2

Crystal structure of glycinamide ribonucleotide transformylase from Escherichia coli at 3.0 A resolution. A target enzyme for chemotherapy.

Chen P, Schulze-Gahmen U, Stura EA, Inglese J, Johnson DL, Marolewski A, Benkovic SJ, Wilson IA. Chen P, et al. Among authors: wilson ia. J Mol Biol. 1992 Sep 5;227(1):283-92. doi: 10.1016/0022-2836(92)90698-j. J Mol Biol. 1992. PMID: 1522592

3

Preliminary crystallographic investigations of glycinamide ribonucleotide transformylase.

Stura EA, Johnson DL, Inglese J, Smith JM, Benkovic SJ, Wilson IA. Stura EA, et al. Among authors: wilson ia. J Biol Chem. 1989 Jun 5;264(16):9703-6. J Biol Chem. 1989. PMID: 2656702 Free article.

4

Towards structure-based drug design: crystal structure of a multisubstrate adduct complex of glycinamide ribonucleotide transformylase at 1.96 A resolution.

Klein C, Chen P, Arevalo JH, Stura EA, Marolewski A, Warren MS, Benkovic SJ, Wilson IA. Klein C, et al. Among authors: wilson ia. J Mol Biol. 1995 May 26;249(1):153-75. doi: 10.1006/jmbi.1995.0286. J Mol Biol. 1995. PMID: 7776369

5

A pH-dependent stabilization of an active site loop observed from low and high pH crystal structures of mutant monomeric glycinamide ribonucleotide transformylase at 1.8 to 1.9 A.

Su Y, Yamashita MM, Greasley SE, Mullen CA, Shim JH, Jennings PA, Benkovic SJ, Wilson IA. Su Y, et al. Among authors: wilson ia. J Mol Biol. 1998 Aug 21;281(3):485-99. doi: 10.1006/jmbi.1998.1931. J Mol Biol. 1998. PMID: 9698564

6

New insights into inhibitor design from the crystal structure and NMR studies of Escherichia coli GAR transformylase in complex with beta-GAR and 10-formyl-5,8,10-trideazafolic acid.

Greasley SE, Yamashita MM, Cai H, Benkovic SJ, Boger DL, Wilson IA. Greasley SE, et al. Among authors: wilson ia. Biochemistry. 1999 Dec 21;38(51):16783-93. doi: 10.1021/bi991888a. Biochemistry. 1999. PMID: 10606510

7

Crystallization and preliminary crystallographic investigations of avian 5-aminoimidazole-4-carboxamide ribonucleotide transformylase-inosine monophosphate cyclohydrolase expressed in Escherichia coli.

Reyes VM, Greasley SE, Stura EA, Beardsley GP, Wilson IA. Reyes VM, et al. Among authors: wilson ia. Acta Crystallogr D Biol Crystallogr. 2000 Aug;56(Pt 8):1051-4. doi: 10.1107/s0907444900007800. Acta Crystallogr D Biol Crystallogr. 2000. PMID: 10944351

8

Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis.

Greasley SE, Horton P, Ramcharan J, Beardsley GP, Benkovic SJ, Wilson IA. Greasley SE, et al. Among authors: wilson ia. Nat Struct Biol. 2001 May;8(5):402-6. doi: 10.1038/87555. Nat Struct Biol. 2001. PMID: 11323713

9

Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase.

Greasley SE, Marsilje TH, Cai H, Baker S, Benkovic SJ, Boger DL, Wilson IA. Greasley SE, et al. Among authors: wilson ia. Biochemistry. 2001 Nov 13;40(45):13538-47. doi: 10.1021/bi011482+. Biochemistry. 2001. PMID: 11695901

10

Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR.

Zhang Y, Desharnais J, Greasley SE, Beardsley GP, Boger DL, Wilson IA. Zhang Y, et al. Among authors: wilson ia. Biochemistry. 2002 Dec 3;41(48):14206-15. doi: 10.1021/bi020522m. Biochemistry. 2002. PMID: 12450384

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