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Antisense oligonucleotide targeted to RIalpha subunit of cAMP-dependent protein kinase (GEM231) enhances therapeutic effectiveness of cancer chemotherapeutic agent irinotecan in nude mice bearing human cancer xenografts: in vivo synergistic activity, pharmacokinetics and host toxicity.
Wang H, Hang J, Shi Z, Li M, Yu D, Kandimalla ER, Agrawal S, Zhang R. Wang H, et al. Among authors: li m. Int J Oncol. 2002 Jul;21(1):73-80. Int J Oncol. 2002. PMID: 12063552
MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53.
Zhang Z, Wang H, Li M, Agrawal S, Chen X, Zhang R. Zhang Z, et al. Among authors: li m. J Biol Chem. 2004 Apr 16;279(16):16000-6. doi: 10.1074/jbc.M312264200. Epub 2004 Feb 3. J Biol Chem. 2004. PMID: 14761977 Free article.
We have previously reported that antisense MDM2 inhibitors have significant anti-tumor activity in multiple human cancer models with various p53 statuses (Zhang, Z., Li, M., Wang, H., Agrawal, S., and Zhang, R. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 11636-11641 …
We have previously reported that antisense MDM2 inhibitors have significant anti-tumor activity in multiple human cancer models with various …
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