Van der Graaf PH - Search Results

1

Pharmacokinetic-pharmacodynamic modelling of the hypothermic and corticosterone effects of the 5-HT1A receptor agonist flesinoxan.

Zuideveld KP, van Gestel A, Peletier LA, Van der Graaf PH, Danhof M. Zuideveld KP, et al. Among authors: van gestel a, van der graaf ph. Eur J Pharmacol. 2002 Jun 7;445(1-2):43-54. doi: 10.1016/s0014-2999(02)01665-5. Eur J Pharmacol. 2002. PMID: 12065193

2

Benextramine acts as an irreversible noncompetitive antagonist of U46619-mediated contraction of the rat small mesenteric artery.

Van der Graaf PH, Stam WB, Saxena PR. Van der Graaf PH, et al. Eur J Pharmacol. 1996 Apr 11;300(3):211-4. doi: 10.1016/0014-2999(96)00040-4. Eur J Pharmacol. 1996. PMID: 8739210

3

The alpha 1-adrenoceptor agonist, SDZ NVI-085, behaves as a potent, competitive antagonist of 5-hydroxytryptamine-induced contraction of rat aorta.

Van der Graaf PH, Apaydin S, Saxena PR. Van der Graaf PH, et al. Eur J Pharmacol. 1995 Dec 20;287(3):309-12. doi: 10.1016/0014-2999(95)00713-x. Eur J Pharmacol. 1995. PMID: 8991806

4

Analysis of drug-receptor interactions in vivo: a new approach in pharmacokinetic-pharmacodynamic modelling.

Van der Graaf PH, Danhof M. Van der Graaf PH, et al. Int J Clin Pharmacol Ther. 1997 Oct;35(10):442-6. Int J Clin Pharmacol Ther. 1997. PMID: 9352393 Review.

5

Mechanism-based pharmacokinetic-pharmacodynamic modeling of the effects of N6-cyclopentyladenosine analogs on heart rate in rat: estimation of in vivo operational affinity and efficacy at adenosine A1 receptors.

Van Der Graaf PH, Van Schaick EA, Math-ot RA, Ijzerman AP, Danhof M. Van Der Graaf PH, et al. Among authors: van schaick ea. J Pharmacol Exp Ther. 1997 Nov;283(2):809-16. J Pharmacol Exp Ther. 1997. PMID: 9353402

6

On the reliability of affinity and efficacy estimates obtained by direct operational model fitting of agonist concentration-effect curves following irreversible receptor inactivation.

Van der Graaf PH, Danhof M. Van der Graaf PH, et al. J Pharmacol Toxicol Methods. 1997 Oct;38(2):81-5. doi: 10.1016/s1056-8719(97)00052-x. J Pharmacol Toxicol Methods. 1997. PMID: 9403778

7

Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of synthetic opioids in the rat: correlation with the interaction at the mu-opioid receptor.

Cox EH, Kerbusch T, Van der Graaf PH, Danhof M. Cox EH, et al. Among authors: van der graaf ph. J Pharmacol Exp Ther. 1998 Mar;284(3):1095-103. J Pharmacol Exp Ther. 1998. PMID: 9495871

8

Functional characterisation of the pharmacological profile of the putative alpha1B-adrenoceptor antagonist, (+)-cyclazosin.

Stam WB, Van der Graaf PH, Saxena PR. Stam WB, et al. Among authors: van der graaf ph. Eur J Pharmacol. 1998 Nov 13;361(1):79-83. doi: 10.1016/s0014-2999(98)00735-3. Eur J Pharmacol. 1998. PMID: 9851544

9

Multivariate quantitative structure-pharmacokinetic relationships (QSPKR) analysis of adenosine A1 receptor agonists in rat.

Van der Graaf PH, Nilsson J, Van Schaick EA, Danhof M. Van der Graaf PH, et al. Among authors: van schaick ea. J Pharm Sci. 1999 Mar;88(3):306-12. doi: 10.1021/js980294a. J Pharm Sci. 1999. PMID: 10052988

10

Mechanism-based pharmacokinetic-pharmacodynamic modeling of antilipolytic effects of adenosine A(1) receptor agonists in rats: prediction of tissue-dependent efficacy in vivo.

Van der Graaf PH, Van Schaick EA, Visser SA, De Greef HJ, Ijzerman AP, Danhof M. Van der Graaf PH, et al. Among authors: van schaick ea. J Pharmacol Exp Ther. 1999 Aug;290(2):702-9. J Pharmacol Exp Ther. 1999. PMID: 10411581

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