Hinnebusch AG - Search Results

1

Serine 577 is phosphorylated and negatively affects the tRNA binding and eIF2alpha kinase activities of GCN2.

Garcia-Barrio M, Dong J, Cherkasova VA, Zhang X, Zhang F, Ufano S, Lai R, Qin J, Hinnebusch AG. Garcia-Barrio M, et al. Among authors: hinnebusch ag. J Biol Chem. 2002 Aug 23;277(34):30675-83. doi: 10.1074/jbc.M203187200. Epub 2002 Jun 17. J Biol Chem. 2002. PMID: 12070158 Free article.

2

Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases.

Ramirez M, Wek RC, Vazquez de Aldana CR, Jackson BM, Freeman B, Hinnebusch AG. Ramirez M, et al. Among authors: hinnebusch ag. Mol Cell Biol. 1992 Dec;12(12):5801-15. doi: 10.1128/mcb.12.12.5801-5815.1992. Mol Cell Biol. 1992. PMID: 1448107 Free PMC article.

3

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast.

Dever TE, Feng L, Wek RC, Cigan AM, Donahue TF, Hinnebusch AG. Dever TE, et al. Among authors: hinnebusch ag. Cell. 1992 Feb 7;68(3):585-96. doi: 10.1016/0092-8674(92)90193-g. Cell. 1992. PMID: 1739968

4

GCD10, a translational repressor of GCN4, is the RNA-binding subunit of eukaryotic translation initiation factor-3.

Garcia-Barrio MT, Naranda T, Vazquez de Aldana CR, Cuesta R, Hinnebusch AG, Hershey JW, Tamame M. Garcia-Barrio MT, et al. Among authors: hinnebusch ag. Genes Dev. 1995 Jul 15;9(14):1781-96. doi: 10.1101/gad.9.14.1781. Genes Dev. 1995. PMID: 7542616 Free article.

5

GCN20, a novel ATP binding cassette protein, and GCN1 reside in a complex that mediates activation of the eIF-2 alpha kinase GCN2 in amino acid-starved cells.

Vazquez de Aldana CR, Marton MJ, Hinnebusch AG. Vazquez de Aldana CR, et al. Among authors: hinnebusch ag. EMBO J. 1995 Jul 3;14(13):3184-99. doi: 10.1002/j.1460-2075.1995.tb07321.x. EMBO J. 1995. PMID: 7621831 Free PMC article.

6

Multicopy tRNA genes functionally suppress mutations in yeast eIF-2 alpha kinase GCN2: evidence for separate pathways coupling GCN4 expression to unchanged tRNA.

Vazquez de Aldana CR, Wek RC, Segundo PS, Truesdell AG, Hinnebusch AG. Vazquez de Aldana CR, et al. Among authors: hinnebusch ag. Mol Cell Biol. 1994 Dec;14(12):7920-32. doi: 10.1128/mcb.14.12.7920-7932.1994. Mol Cell Biol. 1994. PMID: 7969132 Free PMC article.

7

Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast.

Dever TE, Chen JJ, Barber GN, Cigan AM, Feng L, Donahue TF, London IM, Katze MG, Hinnebusch AG. Dever TE, et al. Among authors: hinnebusch ag. Proc Natl Acad Sci U S A. 1993 May 15;90(10):4616-20. doi: 10.1073/pnas.90.10.4616. Proc Natl Acad Sci U S A. 1993. PMID: 8099443 Free PMC article.

8

Mutations in the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2 alpha) that overcome the inhibitory effect of eIF-2 alpha phosphorylation on translation initiation.

Vazquez de Aldana CR, Dever TE, Hinnebusch AG. Vazquez de Aldana CR, et al. Among authors: hinnebusch ag. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7215-9. doi: 10.1073/pnas.90.15.7215. Proc Natl Acad Sci U S A. 1993. PMID: 8102207 Free PMC article.

9

The transcriptional activators BAS1, BAS2, and ABF1 bind positive regulatory sites as the critical elements for adenine regulation of ADE5,7.

Rolfes RJ, Zhang F, Hinnebusch AG. Rolfes RJ, et al. Among authors: hinnebusch ag. J Biol Chem. 1997 May 16;272(20):13343-54. doi: 10.1074/jbc.272.20.13343. J Biol Chem. 1997. PMID: 9148957 Free article.

10

Evidence that complex formation by Bas1p and Bas2p (Pho2p) unmasks the activation function of Bas1p in an adenine-repressible step of ADE gene transcription.

Zhang F, Kirouac M, Zhu N, Hinnebusch AG, Rolfes RJ. Zhang F, et al. Among authors: hinnebusch ag. Mol Cell Biol. 1997 Jun;17(6):3272-83. doi: 10.1128/MCB.17.6.3272. Mol Cell Biol. 1997. PMID: 9154826 Free PMC article.

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