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Mitochondria are direct targets of the lipoxygenase inhibitor MK886. A strategy for cell killing by combined treatment with MK886 and cyclooxygenase inhibitors.
Gugliucci A, Ranzato L, Scorrano L, Colonna R, Petronilli V, Cusan C, Prato M, Mancini M, Pagano F, Bernardi P. Gugliucci A, et al. Among authors: bernardi p. J Biol Chem. 2002 Aug 30;277(35):31789-95. doi: 10.1074/jbc.M204450200. Epub 2002 Jun 21. J Biol Chem. 2002. PMID: 12080072 Free article.
Treatment with 1 microM MK886 plus indomethacin sensitized cells to killing by exogenous arachidonic acid, which induces PTP opening and cytochrome c release (Scorrano, L., Penzo, D., Petronilli, V., Pagano, F., and Bernardi, P. (2001) J. Biol. Chem. 276, 12035-1204 …
Treatment with 1 microM MK886 plus indomethacin sensitized cells to killing by exogenous arachidonic acid, which induces PTP opening and cyt …
Modulation of the mitochondrial megachannel by divalent cations and protons.
Szabó I, Bernardi P, Zoratti M. Szabó I, et al. Among authors: bernardi p. J Biol Chem. 1992 Feb 15;267(5):2940-6. J Biol Chem. 1992. PMID: 1371109 Free article.
As illustrated in the companion paper (Bernardi, P., Vassanelli, S., Veronese, P., Colonna, R., Szabo, I., and Zoratti, M. (1992) J. ...
As illustrated in the companion paper (Bernardi, P., Vassanelli, S., Veronese, P., Colonna, R., Szabo, I., and Zoratti, …
Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations.
Bernardi P, Vassanelli S, Veronese P, Colonna R, Szabó I, Zoratti M. Bernardi P, et al. J Biol Chem. 1992 Feb 15;267(5):2934-9. J Biol Chem. 1992. PMID: 1737749 Free article.
Since PhAsO induces the PTP even in the presence of excess EGTA and in the absence of respiration (Lenartowicz, E., Bernardi, P., and Azzone, G.F. (1991) J. Bioenerg. Biomembr. 23, 679-688), we have been able to study the Ca2+ dependence of the induction process. .. …
Since PhAsO induces the PTP even in the presence of excess EGTA and in the absence of respiration (Lenartowicz, E., Bernardi, P …
Regulation of the permeability transition pore, a voltage-dependent mitochondrial channel inhibited by cyclosporin A.
Petronilli V, Nicolli A, Costantini P, Colonna R, Bernardi P. Petronilli V, et al. Among authors: bernardi p. Biochim Biophys Acta. 1994 Aug 30;1187(2):255-9. doi: 10.1016/0005-2728(94)90122-8. Biochim Biophys Acta. 1994. PMID: 7521212
Many physiological and pathological effectors, including Ca2+ and ADP, modulate MTP operation directly through changes of the gating potential rather than indirectly through changes of the membrane potential (Petronilli, V., Cola, C., Massari, S., Colonna, R. and Bernardi, …
Many physiological and pathological effectors, including Ca2+ and ADP, modulate MTP operation directly through changes of the gating potenti …
536 results