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Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53.
Hansson LO, Friedler A, Freund S, Rudiger S, Fersht AR. Hansson LO, et al. Among authors: fersht ar. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10305-9. doi: 10.1073/pnas.122347199. Epub 2002 Jul 17. Proc Natl Acad Sci U S A. 2002. PMID: 12124396 Free PMC article.
Regulation of DNA binding of p53 by its C-terminal domain.
Weinberg RL, Freund SM, Veprintsev DB, Bycroft M, Fersht AR. Weinberg RL, et al. Among authors: fersht ar. J Mol Biol. 2004 Sep 17;342(3):801-11. doi: 10.1016/j.jmb.2004.07.042. J Mol Biol. 2004. PMID: 15342238
The central region of HDM2 provides a second binding site for p53.
Yu GW, Rudiger S, Veprintsev D, Freund S, Fernandez-Fernandez MR, Fersht AR. Yu GW, et al. Among authors: fersht ar. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1227-32. doi: 10.1073/pnas.0510343103. Epub 2006 Jan 23. Proc Natl Acad Sci U S A. 2006. PMID: 16432196 Free PMC article.
Core domain interactions in full-length p53 in solution.
Veprintsev DB, Freund SM, Andreeva A, Rutledge SE, Tidow H, Cañadillas JM, Blair CM, Fersht AR. Veprintsev DB, et al. Among authors: fersht ar. Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2115-9. doi: 10.1073/pnas.0511130103. Epub 2006 Feb 6. Proc Natl Acad Sci U S A. 2006. PMID: 16461914 Free PMC article.
Solution structure of p53 core domain: structural basis for its instability.
Cañadillas JM, Tidow H, Freund SM, Rutherford TJ, Ang HC, Fersht AR. Cañadillas JM, et al. Among authors: fersht ar. Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2109-14. doi: 10.1073/pnas.0510941103. Epub 2006 Feb 6. Proc Natl Acad Sci U S A. 2006. PMID: 16461916 Free PMC article.
537 results