Friedler A - Search Results

1

Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53.

Hansson LO, Friedler A, Freund S, Rudiger S, Fersht AR. Hansson LO, et al. Among authors: friedler a. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10305-9. doi: 10.1073/pnas.122347199. Epub 2002 Jul 17. Proc Natl Acad Sci U S A. 2002. PMID: 12124396 Free PMC article.

2

A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants.

Friedler A, Hansson LO, Veprintsev DB, Freund SM, Rippin TM, Nikolova PV, Proctor MR, Rüdiger S, Fersht AR. Friedler A, et al. Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):937-42. doi: 10.1073/pnas.241629998. Epub 2002 Jan 8. Proc Natl Acad Sci U S A. 2002. PMID: 11782540 Free PMC article.

3

Molecular mechanism of the interaction between MDM2 and p53.

Schon O, Friedler A, Bycroft M, Freund SM, Fersht AR. Schon O, et al. Among authors: friedler a. J Mol Biol. 2002 Oct 25;323(3):491-501. doi: 10.1016/s0022-2836(02)00852-5. J Mol Biol. 2002. PMID: 12381304

4

Kinetic instability of p53 core domain mutants: implications for rescue by small molecules.

Friedler A, Veprintsev DB, Hansson LO, Fersht AR. Friedler A, et al. J Biol Chem. 2003 Jun 27;278(26):24108-12. doi: 10.1074/jbc.M302458200. Epub 2003 Apr 16. J Biol Chem. 2003. PMID: 12700230 Free article.

5

Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide.

Issaeva N, Friedler A, Bozko P, Wiman KG, Fersht AR, Selivanova G. Issaeva N, et al. Among authors: friedler a. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13303-7. doi: 10.1073/pnas.1835733100. Epub 2003 Oct 31. Proc Natl Acad Sci U S A. 2003. PMID: 14595027 Free PMC article.

6

Structural distortion of p53 by the mutation R249S and its rescue by a designed peptide: implications for "mutant conformation".

Friedler A, DeDecker BS, Freund SM, Blair C, Rüdiger S, Fersht AR. Friedler A, et al. J Mol Biol. 2004 Feb 6;336(1):187-96. doi: 10.1016/j.jmb.2003.12.005. J Mol Biol. 2004. PMID: 14741214

7

Binding of p53-derived ligands to MDM2 induces a variety of long range conformational changes.

Schon O, Friedler A, Freund S, Fersht AR. Schon O, et al. Among authors: friedler a. J Mol Biol. 2004 Feb 6;336(1):197-202. doi: 10.1016/j.jmb.2003.11.051. J Mol Biol. 2004. PMID: 14741215

8

Binding of Rad51 and other peptide sequences to a promiscuous, highly electrostatic binding site in p53.

Friedler A, Veprintsev DB, Rutherford T, von Glos KI, Fersht AR. Friedler A, et al. J Biol Chem. 2005 Mar 4;280(9):8051-9. doi: 10.1074/jbc.M411176200. Epub 2004 Dec 20. J Biol Chem. 2005. PMID: 15611070 Free article.

9

Modulation of binding of DNA to the C-terminal domain of p53 by acetylation.

Friedler A, Veprintsev DB, Freund SM, von Glos KI, Fersht AR. Friedler A, et al. Structure. 2005 Apr;13(4):629-36. doi: 10.1016/j.str.2005.01.020. Structure. 2005. PMID: 15837201 Free article.

10

Energy-dependent nucleolar localization of p53 in vitro requires two discrete regions within the p53 carboxyl terminus.

Karni-Schmidt O, Friedler A, Zupnick A, McKinney K, Mattia M, Beckerman R, Bouvet P, Sheetz M, Fersht A, Prives C. Karni-Schmidt O, et al. Among authors: friedler a. Oncogene. 2007 May 31;26(26):3878-91. doi: 10.1038/sj.onc.1210162. Epub 2007 Jan 22. Oncogene. 2007. PMID: 17237827

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