Chaddock JA - Search Results

1

Expression and purification of catalytically active, non-toxic endopeptidase derivatives of Clostridium botulinum toxin type A.

Chaddock JA, Herbert MH, Ling RJ, Alexander FC, Fooks SJ, Revell DF, Quinn CP, Shone CC, Foster KA. Chaddock JA, et al. Protein Expr Purif. 2002 Jul;25(2):219-28. doi: 10.1016/s1046-5928(02)00002-5. Protein Expr Purif. 2002. PMID: 12135553

2

Inhibition of release of neurotransmitters from rat dorsal root ganglia by a novel conjugate of a Clostridium botulinum toxin A endopeptidase fragment and Erythrina cristagalli lectin.

Duggan MJ, Quinn CP, Chaddock JA, Purkiss JR, Alexander FC, Doward S, Fooks SJ, Friis LM, Hall YH, Kirby ER, Leeds N, Moulsdale HJ, Dickenson A, Green GM, Rahman W, Suzuki R, Shone CC, Foster KA. Duggan MJ, et al. Among authors: chaddock ja. J Biol Chem. 2002 Sep 20;277(38):34846-52. doi: 10.1074/jbc.M202902200. Epub 2002 Jul 8. J Biol Chem. 2002. PMID: 12105193 Free article.

3

Isolation of the gene and large-scale expression and purification of recombinant Erythrina cristagalli lectin.

Stancombe PR, Alexander FC, Ling R, Matheson MA, Shone CC, Chaddock JA. Stancombe PR, et al. Among authors: chaddock ja. Protein Expr Purif. 2003 Aug;30(2):283-92. doi: 10.1016/s1046-5928(03)00125-6. Protein Expr Purif. 2003. PMID: 12880778

4

Retargeted clostridial endopeptidases: inhibition of nociceptive neurotransmitter release in vitro, and antinociceptive activity in in vivo models of pain.

Chaddock JA, Purkiss JR, Alexander FC, Doward S, Fooks SJ, Friis LM, Hall YH, Kirby ER, Leeds N, Moulsdale HJ, Dickenson A, Green GM, Rahman W, Suzuki R, Duggan MJ, Quinn CP, Shone CC, Foster KA. Chaddock JA, et al. Mov Disord. 2004 Mar;19 Suppl 8:S42-7. doi: 10.1002/mds.20008. Mov Disord. 2004. PMID: 15027053

5

Preparation of specifically activatable endopeptidase derivatives of Clostridium botulinum toxins type A, B, and C and their applications.

Sutton JM, Wayne J, Scott-Tucker A, O'Brien SM, Marks PM, Alexander FC, Shone CC, Chaddock JA. Sutton JM, et al. Among authors: chaddock ja. Protein Expr Purif. 2005 Mar;40(1):31-41. doi: 10.1016/j.pep.2004.06.023. Protein Expr Purif. 2005. PMID: 15721769

6

Inhibition of vesicular secretion in both neuronal and nonneuronal cells by a retargeted endopeptidase derivative of Clostridium botulinum neurotoxin type A.

Chaddock JA, Purkiss JR, Friis LM, Broadbridge JD, Duggan MJ, Fooks SJ, Shone CC, Quinn CP, Foster KA. Chaddock JA, et al. Infect Immun. 2000 May;68(5):2587-93. doi: 10.1128/IAI.68.5.2587-2593.2000. Infect Immun. 2000. PMID: 10768948 Free PMC article.

7

A conjugate composed of nerve growth factor coupled to a non-toxic derivative of Clostridium botulinum neurotoxin type A can inhibit neurotransmitter release in vitro.

Chaddock JA, Purkiss JR, Duggan MJ, Quinn CP, Shone CC, Foster KA. Chaddock JA, et al. Growth Factors. 2000;18(2):147-55. doi: 10.3109/08977190009003240. Growth Factors. 2000. PMID: 11019785

8

Novel application of an in vitro technique to the detection and quantification of botulinum neurotoxin antibodies.

Hall YH, Chaddock JA, Moulsdale HJ, Kirby ER, Alexander FC, Marks JD, Foster KA. Hall YH, et al. Among authors: chaddock ja. J Immunol Methods. 2004 May;288(1-2):55-60. doi: 10.1016/j.jim.2004.02.011. J Immunol Methods. 2004. PMID: 15183085

9

Engineered botulinum neurotoxins as new therapeutics.

Masuyer G, Chaddock JA, Foster KA, Acharya KR. Masuyer G, et al. Among authors: chaddock ja. Annu Rev Pharmacol Toxicol. 2014;54:27-51. doi: 10.1146/annurev-pharmtox-011613-135935. Epub 2013 Aug 30. Annu Rev Pharmacol Toxicol. 2014. PMID: 24016211 Review.

10

Re-engineering the target specificity of Clostridial neurotoxins - a route to novel therapeutics.

Foster KA, Adams EJ, Durose L, Cruttwell CJ, Marks E, Shone CC, Chaddock JA, Cox CL, Heaton C, Sutton JM, Wayne J, Alexander FC, Rogers DF. Foster KA, et al. Among authors: chaddock ja. Neurotox Res. 2006 Apr;9(2-3):101-7. doi: 10.1007/BF03354881. Neurotox Res. 2006. PMID: 16785105

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