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Increased O-glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic beta-cells.
D'Alessandris C, Andreozzi F, Federici M, Cardellini M, Brunetti A, Ranalli M, Del Guerra S, Lauro D, Del Prato S, Marchetti P, Lauro R, Sesti G. D'Alessandris C, et al. Among authors: lauro r, lauro d. FASEB J. 2004 Jun;18(9):959-61. doi: 10.1096/fj.03-0725fje. Epub 2004 Apr 1. FASEB J. 2004. PMID: 15059979
Relationship between plasma free fatty acids and uncoupling protein-3 gene expression in skeletal muscle of obese subjects: in vitro evidence of a causal link.
Sbraccia P, D'Adamo M, Leonetti F, Buongiorno A, Silecchia G, Basso MS, Tamburrano G, Lauro D, Federici M, Di Daniele N, Lauro R. Sbraccia P, et al. Among authors: lauro r, lauro d. Clin Endocrinol (Oxf). 2002 Aug;57(2):199-207. doi: 10.1046/j.1365-2265.2002.01593.x. Clin Endocrinol (Oxf). 2002. PMID: 12153598
Polymorphisms of the insulin receptor substrate-2 in patients with type 2 diabetes.
D'Alfonso R, Marini MA, Frittitta L, Sorge R, Frontoni S, Porzio O, Mariani LM, Lauro D, Gambardella S, Trischitta V, Federici M, Lauro R, Sesti G. D'Alfonso R, et al. Among authors: lauro r, lauro d. J Clin Endocrinol Metab. 2003 Jan;88(1):317-22. doi: 10.1210/jc.2002-020807. J Clin Endocrinol Metab. 2003. PMID: 12519871
Chronic hyperglycemia impairs insulin secretion by affecting insulin receptor expression, splicing, and signaling in RIN beta cell line and human islets of Langerhans.
Hribal ML, Perego L, Lovari S, Andreozzi F, Menghini R, Perego C, Finzi G, Usellini L, Placidi C, Capella C, Guzzi V, Lauro D, Bertuzzi F, Davalli A, Pozza G, Pontiroli A, Federici M, Lauro R, Brunetti A, Folli F, Sesti G. Hribal ML, et al. Among authors: lauro r, lauro d. FASEB J. 2003 Jul;17(10):1340-2. doi: 10.1096/fj.02-0685fje. Epub 2003 May 8. FASEB J. 2003. PMID: 12738810
The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients.
Marini MA, Frontoni S, Mineo D, Bracaglia D, Cardellini M, De Nicolais P, Baroni A, D'Alfonso R, Perna M, Lauro D, Federici M, Gambardella S, Lauro R, Sesti G. Marini MA, et al. Among authors: lauro r, lauro d. J Clin Endocrinol Metab. 2003 Jul;88(7):3368-71. doi: 10.1210/jc.2002-021716. J Clin Endocrinol Metab. 2003. PMID: 12843189
The -866A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistance and increased risk of type 2 diabetes.
D'Adamo M, Perego L, Cardellini M, Marini MA, Frontoni S, Andreozzi F, Sciacqua A, Lauro D, Sbraccia P, Federici M, Paganelli M, Pontiroli AE, Lauro R, Perticone F, Folli F, Sesti G. D'Adamo M, et al. Among authors: lauro r, lauro d. Diabetes. 2004 Jul;53(7):1905-10. doi: 10.2337/diabetes.53.7.1905. Diabetes. 2004. PMID: 15220218
Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha.
Federici M, Hribal ML, Menghini R, Kanno H, Marchetti V, Porzio O, Sunnarborg SW, Rizza S, Serino M, Cunsolo V, Lauro D, Mauriello A, Smookler DS, Sbraccia P, Sesti G, Lee DC, Khokha R, Accili D, Lauro R. Federici M, et al. Among authors: lauro r, lauro d. J Clin Invest. 2005 Dec;115(12):3494-505. doi: 10.1172/JCI26052. Epub 2005 Nov 17. J Clin Invest. 2005. PMID: 16294222 Free PMC article.
396 results