Zimmerman DM - Search Results

1

Discovery of an opioid kappa receptor selective pure antagonist from a library of N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphans.

Thomas JB, Atkinson RN, Namdev N, Rothman RB, Gigstad KM, Fix SE, Mascarella SW, Burgess JP, Vinson NA, Xu H, Dersch CM, Cantrell BE, Zimmerman DM, Carroll FI. Thomas JB, et al. Among authors: zimmerman dm. J Med Chem. 2002 Aug 1;45(16):3524-30. doi: 10.1021/jm020084h. J Med Chem. 2002. PMID: 12139463

2

Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a novel potent and selective opioid kappa receptor antagonist.

Thomas JB, Atkinson RN, Vinson NA, Catanzaro JL, Perretta CL, Fix SE, Mascarella SW, Rothman RB, Xu H, Dersch CM, Cantrell BE, Zimmerman DM, Carroll FI. Thomas JB, et al. Among authors: zimmerman dm. J Med Chem. 2003 Jul 3;46(14):3127-37. doi: 10.1021/jm030094y. J Med Chem. 2003. PMID: 12825951

3

Discovery of the first N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphan to possess highly potent and selective opioid delta receptor antagonist activity.

Carroll FI, Zhang L, Mascarella SW, Navarro HA, Rothman RB, Cantrell BE, Zimmerman DM, Thomas JB. Carroll FI, et al. Among authors: zimmerman dm. J Med Chem. 2004 Jan 15;47(2):281-4. doi: 10.1021/jm030419a. J Med Chem. 2004. PMID: 14711299

4

Importance of phenolic address groups in opioid kappa receptor selective antagonists.

Thomas JB, Fix SE, Rothman RB, Mascarella SW, Dersch CM, Cantrell BE, Zimmerman DM, Carroll FI. Thomas JB, et al. Among authors: zimmerman dm. J Med Chem. 2004 Feb 12;47(4):1070-3. doi: 10.1021/jm030467v. J Med Chem. 2004. PMID: 14761209

5

Investigation of the N-substituent conformation governing potency and mu receptor subtype-selectivity in (+)-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonists.

Thomas JB, Mascarella SW, Rothman RB, Partilla JS, Xu H, McCullough KB, Dersch CM, Cantrell BE, Zimmerman DM, Carroll FI. Thomas JB, et al. Among authors: zimmerman dm. J Med Chem. 1998 May 21;41(11):1980-90. doi: 10.1021/jm980063g. J Med Chem. 1998. PMID: 9599247

6

N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists.

Thomas JB, Zheng X, Mascarella SW, Rothman RB, Dersch CM, Partilla JS, Flippen-Anderson JL, George CF, Cantrell BE, Zimmerman DM, Carroll FI. Thomas JB, et al. Among authors: zimmerman dm. J Med Chem. 1998 Oct 8;41(21):4143-9. doi: 10.1021/jm980290i. J Med Chem. 1998. PMID: 9767649

7

Identification of an opioid kappa receptor subtype-selective N-substituent for (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine.

Thomas JB, Fall MJ, Cooper JB, Rothman RB, Mascarella SW, Xu H, Partilla JS, Dersch CM, McCullough KB, Cantrell BE, Zimmerman DM, Carroll FI. Thomas JB, et al. Among authors: zimmerman dm. J Med Chem. 1998 Dec 17;41(26):5188-97. doi: 10.1021/jm980511k. J Med Chem. 1998. PMID: 9857089

8

N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[g]isoquinolines are opioid receptor pure antagonists.

Thomas JB, Mascarella SW, Burgess JP, Xu H, McCullough KB, Rothman RB, Flippen-Anderson JL, George CF, Cantrell BE, Zimmerman DM, Carroll FI. Thomas JB, et al. Among authors: zimmerman dm. Bioorg Med Chem Lett. 1998 Nov 17;8(22):3149-52. doi: 10.1016/s0960-894x(98)00576-9. Bioorg Med Chem Lett. 1998. PMID: 9873693

9

Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity.

Thomas JB, Atkinson RN, Rothman RB, Fix SE, Mascarella SW, Vinson NA, Xu H, Dersch CM, Lu Y, Cantrell BE, Zimmerman DM, Carroll FI. Thomas JB, et al. Among authors: zimmerman dm. J Med Chem. 2001 Aug 16;44(17):2687-90. doi: 10.1021/jm015521r. J Med Chem. 2001. PMID: 11495579

10

Synthesis and analgesic properties of N-substituted trans-4a-aryldecahydroisoquinolines.

Zimmerman DM, Cantrell BE, Swartzendruber JK, Jones ND, Mendelsohn LG, Leander JD, Nickander RC. Zimmerman DM, et al. J Med Chem. 1988 Mar;31(3):555-60. doi: 10.1021/jm00398a011. J Med Chem. 1988. PMID: 2831363

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