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Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 1. Discovery and optimization of salicylaldehyde thiosemicarbazone thrombopoietin mimics.
Duffy KJ, Shaw AN, Delorme E, Dillon SB, Erickson-Miller C, Giampa L, Huang Y, Keenan RM, Lamb P, Liu N, Miller SG, Price AT, Rosen J, Smith H, Wiggall KJ, Zhang L, Luengo JI. Duffy KJ, et al. Among authors: liu n. J Med Chem. 2002 Aug 15;45(17):3573-5. doi: 10.1021/jm025535c. J Med Chem. 2002. PMID: 12166928
Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 2. Rational design of naphtho[1,2-d]imidazole thrombopoietin mimics.
Duffy KJ, Price AT, Delorme E, Dillon SB, Duquenne C, Erickson-Miller C, Giampa L, Huang Y, Keenan RM, Lamb P, Liu N, Miller SG, Rosen J, Shaw AN, Smith H, Wiggall KJ, Zhang L, Luengo JI. Duffy KJ, et al. Among authors: liu n. J Med Chem. 2002 Aug 15;45(17):3576-8. doi: 10.1021/jm0255365. J Med Chem. 2002. PMID: 12166929
Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis.
Duffy KJ, Darcy MG, Delorme E, Dillon SB, Eppley DF, Erickson-Miller C, Giampa L, Hopson CB, Huang Y, Keenan RM, Lamb P, Leong L, Liu N, Miller SG, Price AT, Rosen J, Shah R, Shaw TN, Smith H, Stark KC, Tian SS, Tyree C, Wiggall KJ, Zhang L, Luengo JI. Duffy KJ, et al. Among authors: liu n. J Med Chem. 2001 Oct 25;44(22):3730-45. doi: 10.1021/jm010283l. J Med Chem. 2001. PMID: 11606138
3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase.
Tedesco R, Shaw AN, Bambal R, Chai D, Concha NO, Darcy MG, Dhanak D, Fitch DM, Gates A, Gerhardt WG, Halegoua DL, Han C, Hofmann GA, Johnston VK, Kaura AC, Liu N, Keenan RM, Lin-Goerke J, Sarisky RT, Wiggall KJ, Zimmerman MN, Duffy KJ. Tedesco R, et al. Among authors: liu n. J Med Chem. 2006 Feb 9;49(3):971-83. doi: 10.1021/jm050855s. J Med Chem. 2006. PMID: 16451063
Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase.
Shaw AN, Tedesco R, Bambal R, Chai D, Concha NO, Darcy MG, Dhanak D, Duffy KJ, Fitch DM, Gates A, Johnston VK, Keenan RM, Lin-Goerke J, Liu N, Sarisky RT, Wiggall KJ, Zimmerman MN. Shaw AN, et al. Among authors: liu n. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4350-3. doi: 10.1016/j.bmcl.2009.05.091. Epub 2009 May 28. Bioorg Med Chem Lett. 2009. PMID: 19515564
13,216 results
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