van Aalten DM - Search Results

1

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site.

Biondi RM, Komander D, Thomas CC, Lizcano JM, Deak M, Alessi DR, van Aalten DM. Biondi RM, et al. Among authors: van aalten dm. EMBO J. 2002 Aug 15;21(16):4219-28. doi: 10.1093/emboj/cdf437. EMBO J. 2002. PMID: 12169624 Free PMC article.

2

Crystal structure of FadR, a fatty acid-responsive transcription factor with a novel acyl coenzyme A-binding fold.

van Aalten DM, DiRusso CC, Knudsen J, Wierenga RK. van Aalten DM, et al. EMBO J. 2000 Oct 2;19(19):5167-77. doi: 10.1093/emboj/19.19.5167. EMBO J. 2000. PMID: 11013219 Free PMC article.

3

The structural basis of acyl coenzyme A-dependent regulation of the transcription factor FadR.

van Aalten DM, DiRusso CC, Knudsen J. van Aalten DM, et al. EMBO J. 2001 Apr 17;20(8):2041-50. doi: 10.1093/emboj/20.8.2041. EMBO J. 2001. PMID: 11296236 Free PMC article.

4

Structural insights into the catalytic mechanism of a family 18 exo-chitinase.

van Aalten DM, Komander D, Synstad B, Gåseidnes S, Peter MG, Eijsink VG. van Aalten DM, et al. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):8979-84. doi: 10.1073/pnas.151103798. Proc Natl Acad Sci U S A. 2001. PMID: 11481469 Free PMC article.

5

Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity.

Thomas CC, Dowler S, Deak M, Alessi DR, van Aalten DM. Thomas CC, et al. Among authors: van aalten dm. Biochem J. 2001 Sep 1;358(Pt 2):287-94. doi: 10.1042/0264-6021:3580287. Biochem J. 2001. PMID: 11513726 Free PMC article.

6

Psammaplin A, a chitinase inhibitor isolated from the Fijian marine sponge Aplysinella rhax.

Tabudravu JN, Eijsink VG, Gooday GW, Jaspars M, Komander D, Legg M, Synstad B, van Aalten DM. Tabudravu JN, et al. Among authors: van aalten dm. Bioorg Med Chem. 2002 Apr;10(4):1123-8. doi: 10.1016/s0968-0896(01)00372-8. Bioorg Med Chem. 2002. PMID: 11836123

7

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate.

Thomas CC, Deak M, Alessi DR, van Aalten DM. Thomas CC, et al. Among authors: van aalten dm. Curr Biol. 2002 Jul 23;12(14):1256-62. doi: 10.1016/s0960-9822(02)00972-7. Curr Biol. 2002. PMID: 12176338 Free article.

8

High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family.

Alphey MS, Attrill H, Crocker PR, van Aalten DM. Alphey MS, et al. Among authors: van aalten dm. J Biol Chem. 2003 Jan 31;278(5):3372-7. doi: 10.1074/jbc.M210602200. Epub 2002 Nov 15. J Biol Chem. 2003. PMID: 12438315 Free article.

9

Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition.

Komander D, Kular GS, Bain J, Elliott M, Alessi DR, Van Aalten DM. Komander D, et al. Among authors: van aalten dm. Biochem J. 2003 Oct 15;375(Pt 2):255-62. doi: 10.1042/BJ20031119. Biochem J. 2003. PMID: 12892559 Free PMC article.

10

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change.

Milburn CC, Deak M, Kelly SM, Price NC, Alessi DR, Van Aalten DM. Milburn CC, et al. Among authors: van aalten dm. Biochem J. 2003 Nov 1;375(Pt 3):531-8. doi: 10.1042/BJ20031229. Biochem J. 2003. PMID: 12964941 Free PMC article.

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