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Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151).
Macdonald SJ, Dowle MD, Harrison LA, Clarke GD, Inglis GG, Johnson MR, Shah P, Smith RA, Amour A, Fleetwood G, Humphreys DC, Molloy CR, Dixon M, Godward RE, Wonacott AJ, Singh OM, Hodgson ST, Hardy GW. Macdonald SJ, et al. Among authors: shah p. J Med Chem. 2002 Aug 29;45(18):3878-90. doi: 10.1021/jm020881f. J Med Chem. 2002. PMID: 12190311
Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate.
Slater MJ, Amphlett EM, Andrews DM, Bravi G, Burton G, Cheasty AG, Corfield JA, Ellis MR, Fenwick RH, Fernandes S, Guidetti R, Haigh D, Hartley CD, Howes PD, Jackson DL, Jarvest RL, Lovegrove VL, Medhurst KJ, Parry NR, Price H, Shah P, Singh OM, Stocker R, Thommes P, Wilkinson C, Wonacott A. Slater MJ, et al. Among authors: shah p. J Med Chem. 2007 Mar 8;50(5):897-900. doi: 10.1021/jm061207r. Epub 2007 Feb 2. J Med Chem. 2007. PMID: 17269759
Discovery of potent inhibitors of the lysophospholipase autotaxin.
Shah P, Cheasty A, Foxton C, Raynham T, Farooq M, Gutierrez IF, Lejeune A, Pritchard M, Turnbull A, Pang L, Owen P, Boyd S, Stowell A, Jordan A, Hamilton NM, Hitchin JR, Stockley M, MacDonald E, Quesada MJ, Trivier E, Skeete J, Ovaa H, Moolenaar WH, Ryder H. Shah P, et al. Bioorg Med Chem Lett. 2016 Nov 15;26(22):5403-5410. doi: 10.1016/j.bmcl.2016.10.036. Epub 2016 Oct 14. Bioorg Med Chem Lett. 2016. PMID: 27780639
Basic Science and Pathogenesis.
Murthy SGSS, Natarajan C, Garza KH, Budhwani SM, Bosworth S, Currie J, Mohanty S, Mallipudi MS, Sheth KS, Wong E, Shah P, Green TA, Juarez MEV, Limon A, Lee E, Zhang J, Ferrer M, Krishnan B. Murthy SGSS, et al. Among authors: shah p. Alzheimers Dement. 2024 Dec;20 Suppl 1:e089269. doi: 10.1002/alz.089269. Alzheimers Dement. 2024. PMID: 39751043
Enhanced motivated behavior mediated by pharmacological targeting of the FGF14/Nav1.6 complex in nucleus accumbens neurons.
Dvorak NM, Wadsworth PA, Aquino-Miranda G, Wang P, Engelke DS, Zhou J, Nguyen N, Singh AK, Aceto G, Haghighijoo Z, Smith II, Goode N, Zhou M, Avchalumov Y, Troendle EP, Tapia CM, Chen H, Powell RT, Baumgartner TJ, Singh J, Koff L, Di Re J, Wadsworth AE, Marosi M, Azar MR, Elias K, Lehmann P, Mármol Contreras YM, Shah P, Gutierrez H, Green TA, Ulmschneider MB, D'Ascenzo M, Stephan C, Cui G, Do Monte FH, Zhou J, Laezza F. Dvorak NM, et al. Among authors: shah p. Nat Commun. 2025 Jan 2;16(1):110. doi: 10.1038/s41467-024-55554-7. Nat Commun. 2025. PMID: 39747162 Free article.
Future Training Pathways in Percutaneous Coronary Interventions: Interventional Critical Care, Complex Coronary Interventions, and Interventional Heart Failure.
Vallabhajosyula S, Alasnag M, Boudoulas KD, Davidson LJ, Pyo RT, Riley RF, Shah PB, Velagapudi P, Batchelor WB, Truesdell AG; Critical Care Cardiology Working Group of the American College of Cardiology Interventional Section Leadership Council. Vallabhajosyula S, et al. Among authors: shah pb. JACC Adv. 2024 Oct 14;3(11):101338. doi: 10.1016/j.jacadv.2024.101338. eCollection 2024 Nov. JACC Adv. 2024. PMID: 39741647 Free PMC article. Review.
Editorial Comment.
Shah PV, Koehne EL. Shah PV, et al. J Urol. 2024 Dec 23:101097JU0000000000004379. doi: 10.1097/JU.0000000000004379. Online ahead of print. J Urol. 2024. PMID: 39713950 No abstract available.
7,377 results