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A highly selective, non-hydantoin, non-carboxylic acid inhibitor of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran- 2-sulfonyl)-2-H-pyridazin-3-one.
Mylari BL, Armento SJ, Beebe DA, Conn EL, Coutcher JB, Dina MS, O'Gorman MT, Linhares MC, Martin WH, Oates PJ, Tess DA, Withbroe GJ, Zembrowski WJ. Mylari BL, et al. Among authors: oates pj. J Med Chem. 2003 Jun 5;46(12):2283-6. doi: 10.1021/jm034065z. J Med Chem. 2003. PMID: 12773033
X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase.
Pauly TA, Ekstrom JL, Beebe DA, Chrunyk B, Cunningham D, Griffor M, Kamath A, Lee SE, Madura R, Mcguire D, Subashi T, Wasilko D, Watts P, Mylari BL, Oates PJ, Adams PD, Rath VL. Pauly TA, et al. Among authors: oates pj. Structure. 2003 Sep;11(9):1071-85. doi: 10.1016/s0969-2126(03)00167-9. Structure. 2003. PMID: 12962626 Free article.
A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners.
Mylari BL, Armento SJ, Beebe DA, Conn EL, Coutcher JB, Dina MS, O'Gorman MT, Linhares MC, Martin WH, Oates PJ, Tess DA, Withbroe GJ, Zembrowski WJ. Mylari BL, et al. Among authors: oates pj. J Med Chem. 2005 Oct 6;48(20):6326-39. doi: 10.1021/jm050462t. J Med Chem. 2005. PMID: 16190759
Design and synthesis of a novel family of triazine-based inhibitors of sorbitol dehydrogenase with oral activity: 1-[4-[3R,5S-dimethyl-4-(4-methyl-[1,3,5]triazin-2-yl)-piperazin-1-yl]-[1,3,5]triazin-2-yl]-(R) ethanol.
Mylari BL, Withbroe GJ, Beebe DA, Brackett NS, Conn EL, Coutcher JB, Oates PJ, Zembrowski WJ. Mylari BL, et al. Among authors: oates pj. Bioorg Med Chem. 2003 Sep 15;11(19):4179-88. doi: 10.1016/s0968-0896(03)00490-5. Bioorg Med Chem. 2003. PMID: 12951149
54 results