Khrapko K - Search Results

1

Gene expression profiling of the aging mouse cardiac myocytes.

Bodyak N, Kang PM, Hiromura M, Sulijoadikusumo I, Horikoshi N, Khrapko K, Usheva A. Bodyak N, et al. Among authors: khrapko k. Nucleic Acids Res. 2002 Sep 1;30(17):3788-94. doi: 10.1093/nar/gkf497. Nucleic Acids Res. 2002. PMID: 12202764 Free PMC article.

2

Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions.

Khrapko K, Bodyak N, Thilly WG, van Orsouw NJ, Zhang X, Coller HA, Perls TT, Upton M, Vijg J, Wei JY. Khrapko K, et al. Nucleic Acids Res. 1999 Jun 1;27(11):2434-41. doi: 10.1093/nar/27.11.2434. Nucleic Acids Res. 1999. PMID: 10325435 Free PMC article.

3

Mutation and intracellular clonal expansion of mitochondrial genomes: two synergistic components of the aging process?

Kraytsberg Y, Nekhaeva E, Bodyak NB, Khrapko K. Kraytsberg Y, et al. Among authors: khrapko k. Mech Ageing Dev. 2003 Jan;124(1):49-53. doi: 10.1016/s0047-6374(02)00169-0. Mech Ageing Dev. 2003. PMID: 12618006 Review.

4

Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues.

Nekhaeva E, Bodyak ND, Kraytsberg Y, McGrath SB, Van Orsouw NJ, Pluzhnikov A, Wei JY, Vijg J, Khrapko K. Nekhaeva E, et al. Among authors: khrapko k. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5521-6. doi: 10.1073/pnas.072670199. Epub 2002 Apr 9. Proc Natl Acad Sci U S A. 2002. PMID: 11943860 Free PMC article.

5

Quantification and sequencing of somatic deleted mtDNA in single cells: evidence for partially duplicated mtDNA in aged human tissues.

Bodyak ND, Nekhaeva E, Wei JY, Khrapko K. Bodyak ND, et al. Among authors: khrapko k. Hum Mol Genet. 2001 Jan 1;10(1):17-24. doi: 10.1093/hmg/10.1.17. Hum Mol Genet. 2001. PMID: 11136709

6

Mitochondrial DNA deletions in mice in men: substantia nigra is much less affected in the mouse.

Guo X, Kudryavtseva E, Bodyak N, Nicholas A, Dombrovsky I, Yang D, Kraytsberg Y, Simon DK, Khrapko K. Guo X, et al. Among authors: khrapko k. Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):1159-62. doi: 10.1016/j.bbabio.2010.04.005. Epub 2010 Apr 11. Biochim Biophys Acta. 2010. PMID: 20388490 Free PMC article.

7

Frequent intracellular clonal expansions of somatic mtDNA mutations: significance and mechanisms.

Coller HA, Bodyak ND, Khrapko K. Coller HA, et al. Among authors: khrapko k. Ann N Y Acad Sci. 2002 Apr;959:434-47. doi: 10.1111/j.1749-6632.2002.tb02113.x. Ann N Y Acad Sci. 2002. PMID: 11976216

8

Collection of isolated cells for studying mitochondrial DNA mutations within individual cells.

Kraytsberg Y, Bodyak N, Myerow S, Nicholas A, Ebralidze K, Khrapko K. Kraytsberg Y, et al. Among authors: khrapko k. Methods Mol Biol. 2009;554:315-27. doi: 10.1007/978-1-59745-521-3_20. Methods Mol Biol. 2009. PMID: 19513683

9

Quantitative analysis of somatic mitochondrial DNA mutations by single-cell single-molecule PCR.

Kraytsberg Y, Bodyak N, Myerow S, Nicholas A, Ebralidze K, Khrapko K. Kraytsberg Y, et al. Among authors: khrapko k. Methods Mol Biol. 2009;554:329-69. doi: 10.1007/978-1-59745-521-3_21. Methods Mol Biol. 2009. PMID: 19513684

10

Mitochondrial DNA gene therapy: a gene therapy for aging?

Khrapko K. Khrapko K. Rejuvenation Res. 2005 Spring;8(1):6-8. doi: 10.1089/rej.2005.8.6. Rejuvenation Res. 2005. PMID: 15798368

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