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Phase II study of MEK inhibitor trametinib alone and in combination with AKT inhibitor GSK2141795/uprosertib in patients with metastatic triple negative breast cancer.
Prasath V, Boutrid H, Wesolowski R, Abdel-Rasoul M, Timmers C, Lustberg M, Layman RM, Macrae E, Mrozek E, Shapiro C, Glover K, Vater M, Budd GT, Harris L, Isaacs C, Dees C, Perou CM, Johnson GL, Poklepovic A, Chen H, Villalona-Calero M, Carson W, Stover DG, Ramaswamy B. Prasath V, et al. Among authors: shapiro c. Breast Cancer Res Treat. 2024 Dec 7. doi: 10.1007/s10549-024-07551-z. Online ahead of print. Breast Cancer Res Treat. 2024. PMID: 39644403
Safety and immunogenicity of a modified mRNA-lipid nanoparticle vaccine candidate against COVID-19: Results from a phase 1, dose-escalation study.
Essink BJ, Shapiro C, Isidro MGD, Bradley P, Pragalos A, Bloch M, Santiaguel J, Frias MV, Miyakis S, Alves de Mesquita M, Berrè S, Servais C, Waugh N, Hoffmann C, Baba E, Schönborn-Kellenberger O, Wolz OO, Koch SD, Ganyani T, Boutet P, Mann P, Mueller SO, Ramanathan R, Gaudinski MR, Vanhoutte N. Essink BJ, et al. Among authors: shapiro c. Hum Vaccin Immunother. 2024 Dec 31;20(1):2408863. doi: 10.1080/21645515.2024.2408863. Epub 2024 Oct 18. Hum Vaccin Immunother. 2024. PMID: 39422261 Free PMC article. Clinical Trial.
Phase 1 Trials of PNPLA3 siRNA in I148M Homozygous Patients with MAFLD.
Fabbrini E, Rady B, Koshkina A, Jeon JY, Ayyar VS, Gargano C, DiProspero N, Wendel S, Hegge J, Hamilton H, Ding ZM, Afrazi M, Nicholas A, Pei T, Nakano M, Ouchi S, Saito Y, Yamashita A, Tamamura R, Salazar H, Shapiro C, Yoshihara T, Yonemura T, Inoue S, Matsuoka O, Erion M, Pocai A, Makimura H. Fabbrini E, et al. Among authors: shapiro c. N Engl J Med. 2024 Aug 1;391(5):475-476. doi: 10.1056/NEJMc2402341. N Engl J Med. 2024. PMID: 39083780 Clinical Trial. No abstract available.
838 results