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The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue.
Hsu T, Hingley-Wilson SM, Chen B, Chen M, Dai AZ, Morin PM, Marks CB, Padiyar J, Goulding C, Gingery M, Eisenberg D, Russell RG, Derrick SC, Collins FM, Morris SL, King CH, Jacobs WR Jr. Hsu T, et al. Among authors: russell rg. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12420-5. doi: 10.1073/pnas.1635213100. Epub 2003 Oct 13. Proc Natl Acad Sci U S A. 2003. PMID: 14557547 Free PMC article.
Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccine.
Derrick SC, Evering TH, Sambandamurthy VK, Jalapathy KV, Hsu T, Chen B, Chen M, Russell RG, Junqueira-Kipnis AP, Orme IM, Porcelli SA, Jacobs WR Jr, Morris SL. Derrick SC, et al. Among authors: russell rg. Immunology. 2007 Feb;120(2):192-206. doi: 10.1111/j.1365-2567.2006.02491.x. Epub 2006 Oct 31. Immunology. 2007. PMID: 17076705 Free PMC article.
504 results