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Page 1
SEGRAs: a novel class of anti-inflammatory compounds.
Schäcke H, Hennekes H, Schottelius A, Jaroch S, Lehmann M, Schmees N, Rehwinkel H, Asadullah K. Schäcke H, et al. Among authors: schmees n. Ernst Schering Res Found Workshop. 2002;(40):357-71. doi: 10.1007/978-3-662-04660-9_20. Ernst Schering Res Found Workshop. 2002. PMID: 12355726 Review.
Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects.
Schäcke H, Schottelius A, Döcke WD, Strehlke P, Jaroch S, Schmees N, Rehwinkel H, Hennekes H, Asadullah K. Schäcke H, et al. Among authors: schmees n. Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):227-32. doi: 10.1073/pnas.0300372101. Epub 2003 Dec 23. Proc Natl Acad Sci U S A. 2004. PMID: 14694204 Free PMC article.
Discovery of quinolines as selective glucocorticoid receptor agonists.
Jaroch S, Berger M, Huwe C, Krolikiewicz K, Rehwinkel H, Schäcke H, Schmees N, Skuballa W. Jaroch S, et al. Among authors: schmees n. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5835-8. doi: 10.1016/j.bmcl.2010.07.125. Epub 2010 Aug 3. Bioorg Med Chem Lett. 2010. PMID: 20727743
Discovery of new selective glucocorticoid receptor agonist leads.
Berger M, Rehwinkel H, Schmees N, Schäcke H, Edman K, Wissler L, Reichel A, Jaroch S. Berger M, et al. Among authors: schmees n. Bioorg Med Chem Lett. 2017 Feb 1;27(3):437-442. doi: 10.1016/j.bmcl.2016.12.047. Epub 2016 Dec 23. Bioorg Med Chem Lett. 2017. PMID: 28043796
Effects of a selective glucocorticoid receptor agonist on experimental keratoplasty.
Pleyer U, Yang J, Knapp S, Schäcke H, Schmees N, Orlic N, Otasevic L, De Ruijter M, Ritter T, Keipert S. Pleyer U, et al. Among authors: schmees n. Graefes Arch Clin Exp Ophthalmol. 2005 May;243(5):450-5. doi: 10.1007/s00417-004-0991-y. Epub 2005 Apr 9. Graefes Arch Clin Exp Ophthalmol. 2005. PMID: 15821926
Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone Receptor as Proven in a First-In-Human Study in Postmenopausal Women.
Panknin O, Wagenfeld A, Bone W, Bender E, Nowak-Reppel K, Fernández-Montalván AE, Nubbemeyer R, Bäurle S, Ring S, Schmees N, Prien O, Schäfer M, Friedrich C, Zollner TM, Steinmeyer A, Mueller T, Langer G. Panknin O, et al. Among authors: schmees n. J Med Chem. 2020 Oct 22;63(20):11854-11881. doi: 10.1021/acs.jmedchem.0c01076. Epub 2020 Oct 6. J Med Chem. 2020. PMID: 32960053
Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening.
Gradl S, Steuber H, Weiske J, Szewczyk MM, Schmees N, Siegel S, Stoeckigt D, Christ CD, Li F, Organ S, Abbey M, Kennedy S, Chau I, Trush V, Barsyte-Lovejoy D, Brown PJ, Vedadi M, Arrowsmith C, Husemann M, Badock V, Bauser M, Haegebarth A, Hartung IV, Stresemann C. Gradl S, et al. Among authors: schmees n. SLAS Discov. 2021 Sep;26(8):947-960. doi: 10.1177/24725552211019409. Epub 2021 Jun 21. SLAS Discov. 2021. PMID: 34154424 Free article.
Preclinical evaluation of the BET bromodomain inhibitor BAY 1238097 for the treatment of lymphoma.
Bernasconi E, Gaudio E, Lejeune P, Tarantelli C, Cascione L, Kwee I, Spriano F, Rinaldi A, Mensah AA, Chung E, Stathis A, Siegel S, Schmees N, Ocker M, Zucca E, Haendler B, Bertoni F. Bernasconi E, et al. Among authors: schmees n. Br J Haematol. 2017 Sep;178(6):936-948. doi: 10.1111/bjh.14803. Epub 2017 Jun 27. Br J Haematol. 2017. PMID: 28653353 Free article.
12 results