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Oxypurinol improves coronary and peripheral endothelial function in patients with coronary artery disease.
Baldus S, Köster R, Chumley P, Heitzer T, Rudolph V, Ostad MA, Warnholtz A, Staude HJ, Thuneke F, Koss K, Berger J, Meinertz T, Freeman BA, Münzel T. Baldus S, et al. Free Radic Biol Med. 2005 Nov 1;39(9):1184-90. doi: 10.1016/j.freeradbiomed.2005.06.004. Epub 2005 Aug 10. Free Radic Biol Med. 2005. PMID: 16214034 Free PMC article. Clinical Trial.
Myeloperoxidase, a leukocyte-derived vascular NO oxidase.
Eiserich JP, Baldus S, Brennan ML, Ma W, Zhang C, Tousson A, Castro L, Lusis AJ, Nauseef WM, White CR, Freeman BA. Eiserich JP, et al. Among authors: baldus s. Science. 2002 Jun 28;296(5577):2391-4. doi: 10.1126/science.1106830. Science. 2002. PMID: 12089442
Heparins increase endothelial nitric oxide bioavailability by liberating vessel-immobilized myeloperoxidase.
Baldus S, Rudolph V, Roiss M, Ito WD, Rudolph TK, Eiserich JP, Sydow K, Lau D, Szöcs K, Klinke A, Kubala L, Berglund L, Schrepfer S, Deuse T, Haddad M, Risius T, Klemm H, Reichenspurner HC, Meinertz T, Heitzer T. Baldus S, et al. Circulation. 2006 Apr 18;113(15):1871-8. doi: 10.1161/CIRCULATIONAHA.105.590083. Epub 2006 Apr 10. Circulation. 2006. PMID: 16606792
Bivalirudin decreases NO bioavailability by vascular immobilization of myeloperoxidase.
Rudolph V, Rudolph TK, Schopfer FJ, Bonacci G, Lau D, Szöcs K, Klinke A, Meinertz T, Freeman BA, Baldus S. Rudolph V, et al. Among authors: baldus s. J Pharmacol Exp Ther. 2008 Nov;327(2):324-31. doi: 10.1124/jpet.108.142414. Epub 2008 Aug 13. J Pharmacol Exp Ther. 2008. PMID: 18701766 Free PMC article. Clinical Trial.
689 results