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E-cadherin dis-engagement activates the Rap1 GTPase.
Asuri S, Yan J, Paranavitana NC, Quilliam LA. Asuri S, et al. Among authors: paranavitana nc. J Cell Biochem. 2008 Nov 1;105(4):1027-37. doi: 10.1002/jcb.21902. J Cell Biochem. 2008. PMID: 18767072 Free PMC article.
Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins.
Li Y, Yan J, De P, Chang HC, Yamauchi A, Christopherson KW 2nd, Paranavitana NC, Peng X, Kim C, Munugalavadla V, Kapur R, Chen H, Shou W, Stone JC, Kaplan MH, Dinauer MC, Durden DL, Quilliam LA. Li Y, et al. Among authors: paranavitana nc. J Immunol. 2007 Dec 15;179(12):8322-31. doi: 10.4049/jimmunol.179.12.8322. J Immunol. 2007. PMID: 18056377 Free PMC article.