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Heparin and heparan sulfate disaccharides bind to the exchanger inhibitor peptide region of Na+/Ca2+ exchanger and reduce the cytosolic calcium of smooth muscle cell lines. Requirement of C4-C5 unsaturation and 1--> 4 glycosidic linkage for activity.
Shinjo SK, Tersariol IL, Oliveira V, Nakaie CR, Oshiro ME, Ferreira AT, Santos IA, Dietrich CP, Nader HB. Shinjo SK, et al. Among authors: nader hb. J Biol Chem. 2002 Dec 13;277(50):48227-33. doi: 10.1074/jbc.M205867200. Epub 2002 Oct 8. J Biol Chem. 2002. PMID: 12374809 Free article.
368 results