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Hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin prevents cardiac hypertrophy induced by pressure overload and inhibits p21ras activation.
Indolfi C, Di Lorenzo E, Perrino C, Stingone AM, Curcio A, Torella D, Cittadini A, Cardone L, Coppola C, Cavuto L, Arcucci O, Sacca L, Avvedimento EV, Chiariello M. Indolfi C, et al. Among authors: cardone l. Circulation. 2002 Oct 15;106(16):2118-24. doi: 10.1161/01.cir.0000034047.70205.97. Circulation. 2002. PMID: 12379583
Essential role of A-kinase anchor protein 121 for cAMP signaling to mitochondria.
Affaitati A, Cardone L, de Cristofaro T, Carlucci A, Ginsberg MD, Varrone S, Gottesman ME, Avvedimento EV, Feliciello A. Affaitati A, et al. Among authors: cardone l. J Biol Chem. 2003 Feb 7;278(6):4286-94. doi: 10.1074/jbc.M209941200. Epub 2002 Nov 8. J Biol Chem. 2003. PMID: 12427737 Free article.
Computational drugs repositioning identifies inhibitors of oncogenic PI3K/AKT/P70S6K-dependent pathways among FDA-approved compounds.
Carrella D, Manni I, Tumaini B, Dattilo R, Papaccio F, Mutarelli M, Sirci F, Amoreo CA, Mottolese M, Iezzi M, Ciolli L, Aria V, Bosotti R, Isacchi A, Loreni F, Bardelli A, Avvedimento VE, di Bernardo D, Cardone L. Carrella D, et al. Among authors: cardone l. Oncotarget. 2016 Sep 13;7(37):58743-58758. doi: 10.18632/oncotarget.11318. Oncotarget. 2016. PMID: 27542212 Free PMC article.
Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS-Dependent Pancreatic Ductal Adenocarcinoma.
Mottini C, Tomihara H, Carrella D, Lamolinara A, Iezzi M, Huang JK, Amoreo CA, Buglioni S, Manni I, Robinson FS, Minelli R, Kang Y, Fleming JB, Kim MP, Bristow CA, Trisciuoglio D, Iuliano A, Del Bufalo D, Di Bernardo D, Melisi D, Draetta GF, Ciliberto G, Carugo A, Cardone L. Mottini C, et al. Among authors: cardone l. Cancer Res. 2019 Nov 1;79(21):5612-5625. doi: 10.1158/0008-5472.CAN-19-0187. Epub 2019 Sep 5. Cancer Res. 2019. PMID: 31492820
33 results