Gerwick WH - Search Results

1

The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit.

Chang Z, Flatt P, Gerwick WH, Nguyen VA, Willis CL, Sherman DH. Chang Z, et al. Among authors: gerwick wh. Gene. 2002 Aug 21;296(1-2):235-47. doi: 10.1016/s0378-1119(02)00860-0. Gene. 2002. PMID: 12383521

2

Synthesis of the marine natural product barbamide.

Nguyen VA, Willis CL, Gerwick WH. Nguyen VA, et al. Among authors: gerwick wh. Chem Commun (Camb). 2001 Oct 7;(19):1934-5. doi: 10.1039/b106087m. Chem Commun (Camb). 2001. PMID: 12240226

3

Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula.

Chang Z, Sitachitta N, Rossi JV, Roberts MA, Flatt PM, Jia J, Sherman DH, Gerwick WH. Chang Z, et al. Among authors: gerwick wh. J Nat Prod. 2004 Aug;67(8):1356-67. doi: 10.1021/np0499261. J Nat Prod. 2004. PMID: 15332855

4

Marine natural products as anticancer drugs.

Simmons TL, Andrianasolo E, McPhail K, Flatt P, Gerwick WH. Simmons TL, et al. Among authors: gerwick wh. Mol Cancer Ther. 2005 Feb;4(2):333-42. Mol Cancer Ther. 2005. PMID: 15713904 Review.

5

Characterization of the initial enzymatic steps of barbamide biosynthesis.

Flatt PM, O'Connell SJ, McPhail KL, Zeller G, Willis CL, Sherman DH, Gerwick WH. Flatt PM, et al. Among authors: gerwick wh. J Nat Prod. 2006 Jun;69(6):938-44. doi: 10.1021/np050523q. J Nat Prod. 2006. PMID: 16792414

6

Metabolic coupling of dehydration and decarboxylation in the curacin A pathway: functional identification of a mechanistically diverse enzyme pair.

Gu L, Jia J, Liu H, Håkansson K, Gerwick WH, Sherman DH. Gu L, et al. Among authors: gerwick wh. J Am Chem Soc. 2006 Jul 19;128(28):9014-5. doi: 10.1021/ja0626382. J Am Chem Soc. 2006. PMID: 16834357

7

Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching.

Geders TW, Gu L, Mowers JC, Liu H, Gerwick WH, Håkansson K, Sherman DH, Smith JL. Geders TW, et al. Among authors: gerwick wh. J Biol Chem. 2007 Dec 7;282(49):35954-63. doi: 10.1074/jbc.M703921200. Epub 2007 Oct 10. J Biol Chem. 2007. PMID: 17928301 Free article.

8

GNAT-like strategy for polyketide chain initiation.

Gu L, Geders TW, Wang B, Gerwick WH, Håkansson K, Smith JL, Sherman DH. Gu L, et al. Among authors: gerwick wh. Science. 2007 Nov 9;318(5852):970-4. doi: 10.1126/science.1148790. Science. 2007. PMID: 17991863

9

Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium Lyngbya majuscula.

Ramaswamy AV, Sorrels CM, Gerwick WH. Ramaswamy AV, et al. Among authors: gerwick wh. J Nat Prod. 2007 Dec;70(12):1977-86. doi: 10.1021/np0704250. Epub 2007 Nov 15. J Nat Prod. 2007. PMID: 18001088

10

New tricks from ancient algae: natural products biosynthesis in marine cyanobacteria.

Jones AC, Gu L, Sorrels CM, Sherman DH, Gerwick WH. Jones AC, et al. Among authors: gerwick wh. Curr Opin Chem Biol. 2009 Apr;13(2):216-23. doi: 10.1016/j.cbpa.2009.02.019. Epub 2009 Mar 21. Curr Opin Chem Biol. 2009. PMID: 19307147 Free PMC article. Review.

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