Ruchelman AL - Search Results

1

Diaza- and triazachrysenes: potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435.

Ruchelman AL, Singh SK, Wu X, Ray A, Yang JM, Li TK, Liu A, Liu LF, LaVoie EJ. Ruchelman AL, et al. Bioorg Med Chem Lett. 2002 Nov 18;12(22):3333-6. doi: 10.1016/s0960-894x(02)00737-0. Bioorg Med Chem Lett. 2002. PMID: 12392745

2

5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity.

Ruchelman AL, Singh SK, Ray A, Wu XH, Yang JM, Li TK, Liu A, Liu LF, LaVoie EJ. Ruchelman AL, et al. Bioorg Med Chem. 2003 May 1;11(9):2061-73. doi: 10.1016/s0968-0896(03)00051-8. Bioorg Med Chem. 2003. PMID: 12670657

3

Nitro and amino substitution in the D-ring of 5-(2-dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: effect on topoisomerase-I targeting activity and cytotoxicity.

Singh SK, Ruchelman AL, Li TK, Liu A, Liu LF, LaVoie EJ. Singh SK, et al. Among authors: ruchelman al. J Med Chem. 2003 May 22;46(11):2254-7. doi: 10.1021/jm020498a. J Med Chem. 2003. PMID: 12747798

4

5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones and related compounds as TOP1-targeting agents: influence of structure on the ternary cleavable complex formation.

Kerrigan JE, Pilch DS, Ruchelman AL, Zhou N, Liu A, Liu L, LaVoie EJ. Kerrigan JE, et al. Among authors: ruchelman al. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3395-9. doi: 10.1016/s0960-894x(03)00797-2. Bioorg Med Chem Lett. 2003. PMID: 14505635

5

Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug.

Li TK, Houghton PJ, Desai SD, Daroui P, Liu AA, Hars ES, Ruchelman AL, LaVoie EJ, Liu LF. Li TK, et al. Among authors: ruchelman al. Cancer Res. 2003 Dec 1;63(23):8400-7. Cancer Res. 2003. PMID: 14679002

6

11H-Isoquino[4,3-c]cinnolin-12-ones; novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity.

Ruchelman AL, Singh SK, Ray A, Wu X, Yang JM, Zhou N, Liu A, Liu LF, LaVoie EJ. Ruchelman AL, et al. Bioorg Med Chem. 2004 Feb 15;12(4):795-806. doi: 10.1016/j.bmc.2003.10.061. Bioorg Med Chem. 2004. PMID: 14759740

7

Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: influence on topoisomerase I-targeting activity and cytotoxicity.

Ruchelman AL, Kerrigan JE, Li TK, Zhou N, Liu A, Liu LF, LaVoie EJ. Ruchelman AL, et al. Bioorg Med Chem. 2004 Jul 1;12(13):3731-42. doi: 10.1016/j.bmc.2004.03.076. Bioorg Med Chem. 2004. PMID: 15186859

8

Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity.

Ruchelman AL, Zhu S, Zhou N, Liu A, Liu LF, LaVoie EJ. Ruchelman AL, et al. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5585-9. doi: 10.1016/j.bmcl.2004.08.070. Bioorg Med Chem Lett. 2004. PMID: 15482929

9

5-(2-aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: variation of n-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance.

Ruchelman AL, Houghton PJ, Zhou N, Liu A, Liu LF, LaVoie EJ. Ruchelman AL, et al. J Med Chem. 2005 Feb 10;48(3):792-804. doi: 10.1021/jm049447z. J Med Chem. 2005. PMID: 15689163

10

Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[i]phenanthridine-12-carboxylic acid: potent cytotoxic and topoisomerase I-targeting agents.

Zhu S, Ruchelman AL, Zhou N, Liu AA, Liu LF, LaVoie EJ. Zhu S, et al. Among authors: ruchelman al. Bioorg Med Chem. 2005 Dec 15;13(24):6782-94. doi: 10.1016/j.bmc.2005.07.033. Epub 2005 Sep 8. Bioorg Med Chem. 2005. PMID: 16153852

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