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DARPin-induced reactivation of p53 in HPV-positive cells.
Münick P, Strubel A, Balourdas DI, Funk JS, Mernberger M, Osterburg C, Dreier B, Schaefer JV, Tuppi M, Yüksel B, Schäfer B, Knapp S, Plückthun A, Stiewe T, Joerger AC, Dötsch V. Münick P, et al. Among authors: dreier b. Nat Struct Mol Biol. 2025 Jan 9. doi: 10.1038/s41594-024-01456-7. Online ahead of print. Nat Struct Mol Biol. 2025. PMID: 39789211
DARPins as a novel tool to detect and degrade p73.
Münick P, Zielinski J, Strubel A, Gutfreund N, Dreier B, Schaefer JV, Schäfer B, Gebel J, Osterburg C, Chaikuad A, Knapp S, Plückthun A, Dötsch V. Münick P, et al. Among authors: dreier b. Cell Death Dis. 2024 Dec 18;15(12):909. doi: 10.1038/s41419-024-07304-2. Cell Death Dis. 2024. PMID: 39695090 Free PMC article.
A designed ankyrin-repeat protein that targets Parkinson's disease-associated LRRK2.
Dederer V, Sanz Murillo M, Karasmanis EP, Hatch KS, Chatterjee D, Preuss F, Abdul Azeez KR, Nguyen LV, Galicia C, Dreier B, Plückthun A, Versees W, Mathea S, Leschziner AE, Reck-Peterson SL, Knapp S. Dederer V, et al. Among authors: dreier b. J Biol Chem. 2024 Jul;300(7):107469. doi: 10.1016/j.jbc.2024.107469. Epub 2024 Jun 12. J Biol Chem. 2024. PMID: 38876305 Free PMC article.
mRNA Display Pipeline for Protein Biosensor Construction.
Cui Z, Ayva CE, Liew YJ, Guo Z, Mutschler R, Dreier B, Fiorito MM, Walden P, Howard CB, Ely F, Plückthun A, Pretorius C, Ungerer JP, Buckle AM, Alexandrov K. Cui Z, et al. Among authors: dreier b. ACS Sens. 2024 Jun 28;9(6):2846-2857. doi: 10.1021/acssensors.3c02471. Epub 2024 May 29. ACS Sens. 2024. PMID: 38807313
DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma.
Strubel A, Münick P, Hartmann O, Chaikuad A, Dreier B, Schaefer JV, Gebel J, Osterburg C, Tuppi M, Schäfer B, Buck V, Rosenfeldt M, Knapp S, Plückthun A, Diefenbacher ME, Dötsch V. Strubel A, et al. Among authors: dreier b. Cell Death Dis. 2023 Oct 12;14(10):674. doi: 10.1038/s41419-023-06213-0. Cell Death Dis. 2023. PMID: 37828008 Free PMC article.
68 results