Lai Z - Search Results

1

Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors.

Lai Z, Yang T, Kim YB, Sielecki TM, Diamond MA, Strack P, Rolfe M, Caligiuri M, Benfield PA, Auger KR, Copeland RA. Lai Z, et al. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14734-9. doi: 10.1073/pnas.212428599. Epub 2002 Oct 29. Proc Natl Acad Sci U S A. 2002. PMID: 12407176 Free PMC article.

2

Thermodynamics of p53 binding to hdm2(1-126): effects of phosphorylation and p53 peptide length.

Lai Z, Auger KR, Manubay CM, Copeland RA. Lai Z, et al. Arch Biochem Biophys. 2000 Sep 15;381(2):278-84. doi: 10.1006/abbi.2000.1998. Arch Biochem Biophys. 2000. PMID: 11032416

3

Quantitative assays of Mdm2 ubiquitin ligase activity and other ubiquitin-utilizing enzymes for inhibitor discovery.

Auger KR, Copeland RA, Lai Z. Auger KR, et al. Among authors: lai z. Methods Enzymol. 2005;399:701-17. doi: 10.1016/S0076-6879(05)99046-0. Methods Enzymol. 2005. PMID: 16338390

4

A second p53 binding site in the central domain of Mdm2 is essential for p53 ubiquitination.

Ma J, Martin JD, Zhang H, Auger KR, Ho TF, Kirkpatrick RB, Grooms MH, Johanson KO, Tummino PJ, Copeland RA, Lai Z. Ma J, et al. Among authors: lai z. Biochemistry. 2006 Aug 1;45(30):9238-45. doi: 10.1021/bi060661u. Biochemistry. 2006. PMID: 16866370

5

Steady-state kinetic analysis of human ubiquitin-activating enzyme (E1) using a fluorescently labeled ubiquitin substrate.

Wee KE, Lai Z, Auger KR, Ma J, Horiuchi KY, Dowling RL, Dougherty CS, Corman JI, Wynn R, Copeland RA. Wee KE, et al. Among authors: lai z. J Protein Chem. 2000 Aug;19(6):489-98. doi: 10.1023/a:1026501515450. J Protein Chem. 2000. PMID: 11195973

6

Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization.

Lai Z, Ferry KV, Diamond MA, Wee KE, Kim YB, Ma J, Yang T, Benfield PA, Copeland RA, Auger KR. Lai Z, et al. J Biol Chem. 2001 Aug 17;276(33):31357-67. doi: 10.1074/jbc.M011517200. Epub 2001 Jun 7. J Biol Chem. 2001. PMID: 11397792 Free article.

7

A biochemical rationale for the anticancer effects of Hsp90 inhibitors: slow, tight binding inhibition by geldanamycin and its analogues.

Gooljarsingh LT, Fernandes C, Yan K, Zhang H, Grooms M, Johanson K, Sinnamon RH, Kirkpatrick RB, Kerrigan J, Lewis T, Arnone M, King AJ, Lai Z, Copeland RA, Tummino PJ. Gooljarsingh LT, et al. Among authors: lai z. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7625-30. doi: 10.1073/pnas.0602650103. Epub 2006 May 9. Proc Natl Acad Sci U S A. 2006. PMID: 16684877 Free PMC article.

8

Defining balanced conditions for inhibitor screening assays that target bisubstrate enzymes.

Yang J, Copeland RA, Lai Z. Yang J, et al. Among authors: lai z. J Biomol Screen. 2009 Feb;14(2):111-20. doi: 10.1177/1087057108328763. Epub 2009 Feb 4. J Biomol Screen. 2009. PMID: 19196704

9

An inhibitor binding pocket distinct from the catalytic active site on human beta-APP cleaving enzyme.

Kornacker MG, Lai Z, Witmer M, Ma J, Hendrick J, Lee VG, Riexinger DJ, Mapelli C, Metzler W, Copeland RA. Kornacker MG, et al. Among authors: lai z. Biochemistry. 2005 Aug 30;44(34):11567-73. doi: 10.1021/bi050932l. Biochemistry. 2005. PMID: 16114893

10

Comparative studies of active site-ligand interactions among various recombinant constructs of human beta-amyloid precursor protein cleaving enzyme.

Kopcho LM, Ma J, Marcinkeviciene J, Lai Z, Witmer MR, Cheng J, Yanchunas J, Tredup J, Corbett M, Calambur D, Wittekind M, Paruchuri M, Kothari D, Lee G, Ganguly S, Ramamurthy V, Morin PE, Camac DM, King RW, Lasut AL, Ross OH, Hillman MC, Fish B, Shen K, Dowling RL, Kim YB, Graciani NR, Collins D, Combs AP, George H, Thompson LA, Copeland RA. Kopcho LM, et al. Among authors: lai z. Arch Biochem Biophys. 2003 Feb 15;410(2):307-16. doi: 10.1016/s0003-9861(02)00690-2. Arch Biochem Biophys. 2003. PMID: 12573291

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