Mills G - Search Results

1

Design and synthesis of ethyl pyrrolidine-5,5-trans-lactams as inhibitors of hepatitis C virus NS3/4A protease.

Slater MJ, Andrews DM, Baker G, Bethell SS, Carey S, Chaignot H, Clarke B, Coomber B, Ellis M, Good A, Gray N, Hardy G, Jones P, Mills G, Robinson E. Slater MJ, et al. Among authors: mills g. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3359-62. doi: 10.1016/s0960-894x(02)00789-8. Bioorg Med Chem Lett. 2002. PMID: 12419361

2

Pyrrolidine-5,5-trans-lactams. 1. Synthesis and incorporation into inhibitors of hepatitis C virus NS3/4A protease.

Andrews DM, Carey SJ, Chaignot H, Coomber BA, Gray NM, Hind SL, Jones PS, Mills G, Robinson JE, Slater MJ. Andrews DM, et al. Among authors: mills g. Org Lett. 2002 Dec 12;4(25):4475-8. doi: 10.1021/ol027013x. Org Lett. 2002. PMID: 12465916

3

Pyrrolidine-5,5-trans-lactams. 2. The use of X-ray crystal structure data in the optimization of P3 and P4 substituents.

Andrews DM, Chaignot H, Coomber BA, Good AC, Hind SL, Johnson MR, Jones PS, Mills G, Robinson JE, Skarzynski T, Slater MJ, Somers DO. Andrews DM, et al. Among authors: mills g. Org Lett. 2002 Dec 12;4(25):4479-82. doi: 10.1021/ol027014p. Org Lett. 2002. PMID: 12465917

4

Design and synthesis of spiro-cyclopentenyl and spiro-[1,3]-dithiolanyl substituted pyrrolidine-5,5-trans-lactams as inhibitors of hepatitis C virus NS3/4A protease.

Andrews DM, Jones PS, Mills G, Hind SL, Slater MJ, Trivedi N, Wareing KJ. Andrews DM, et al. Among authors: mills g. Bioorg Med Chem Lett. 2003 May 19;13(10):1657-60. doi: 10.1016/s0960-894x(03)00274-9. Bioorg Med Chem Lett. 2003. PMID: 12729635

5

The design of potent, non-peptidic inhibitors of hepatitis C protease.

Andrews DM, Chaignot HM, Coomber BA, Dowle MD, Hind SL, Johnson MR, Jones PS, Mills G, Patikis A, Pateman TJ, Robinson JE, Slater MJ, Trivedi N. Andrews DM, et al. Among authors: mills g. Eur J Med Chem. 2003 Apr;38(4):339-43. doi: 10.1016/s0223-5234(03)00050-3. Eur J Med Chem. 2003. PMID: 12750019

6

Pyrrolidine-5,5-trans-lactams. 4. Incorporation of a P3/P4 urea leads to potent intracellular inhibitors of hepatitis C virus NS3/4A protease.

Slater MJ, Amphlett EM, Andrews DM, Bamborough P, Carey SJ, Johnson MR, Jones PS, Mills G, Parry NR, Somers DO, Stewart AJ, Skarzynski T. Slater MJ, et al. Among authors: mills g. Org Lett. 2003 Nov 27;5(24):4627-30. doi: 10.1021/ol035826v. Org Lett. 2003. PMID: 14627400

7

Pyrrolidine-5,5-trans-lactams. 5. Pharmacokinetic optimization of inhibitors of hepatitis C virus NS3/4A protease.

Andrews DM, Barnes MC, Dowle MD, Hind SL, Johnson MR, Jones PS, Mills G, Patikis A, Pateman TJ, Redfern TJ, Robinson JE, Slater MJ, Trivedi N. Andrews DM, et al. Among authors: mills g. Org Lett. 2003 Nov 27;5(24):4631-4. doi: 10.1021/ol035827n. Org Lett. 2003. PMID: 14627401

8

6,6'-Bis(2-hydroxyphenyl)-2,2'-bipyridine manganese(III) complexes: a novel series of superoxide dismutase and catalase mimetics.

Giblin GM, Box PC, Campbell IB, Hancock AP, Roomans S, Mills GI, Molloy C, Tranter GE, Walker AL, Doctrow SR, Huffman K, Malfroy B. Giblin GM, et al. Among authors: mills gi. Bioorg Med Chem Lett. 2001 Jun 4;11(11):1367-70. doi: 10.1016/s0960-894x(01)00217-7. Bioorg Med Chem Lett. 2001. PMID: 11378356

9

Peripherally acting enkephalin analogues. 2. Polar tri- and tetrapeptides.

Hardy GW, Lowe LA, Mills G, Sang PY, Simpkin DS, Follenfant RL, Shankley C, Smith TW. Hardy GW, et al. Among authors: mills g. J Med Chem. 1989 May;32(5):1108-18. doi: 10.1021/jm00125a028. J Med Chem. 1989. PMID: 2709377

10

Dimeric zanamivir conjugates with various linking groups are potent, long-lasting inhibitors of influenza neuraminidase including H5N1 avian influenza.

Macdonald SJ, Cameron R, Demaine DA, Fenton RJ, Foster G, Gower D, Hamblin JN, Hamilton S, Hart GJ, Hill AP, Inglis GG, Jin B, Jones HT, McConnell DB, McKimm-Breschkin J, Mills G, Nguyen V, Owens IJ, Parry N, Shanahan SE, Smith D, Watson KG, Wu WY, Tucker SP. Macdonald SJ, et al. Among authors: mills g. J Med Chem. 2005 Apr 21;48(8):2964-71. doi: 10.1021/jm040891b. J Med Chem. 2005. PMID: 15828835

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