Konishi Y - Search Results

1

Design of noncovalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides.

Chowdhury SF, Sivaraman J, Wang J, Devanathan G, Lachance P, Qi H, Ménard R, Lefebvre J, Konishi Y, Cygler M, Sulea T, Purisima EO. Chowdhury SF, et al. Among authors: konishi y. J Med Chem. 2002 Nov 21;45(24):5321-9. doi: 10.1021/jm020238t. J Med Chem. 2002. PMID: 12431059

2

Design of P1' and P3' residues of trivalent thrombin inhibitors and their crystal structures.

Slon-Usakiewicz JJ, Sivaraman J, Li Y, Cygler M, Konishi Y. Slon-Usakiewicz JJ, et al. Among authors: konishi y. Biochemistry. 2000 Mar 7;39(9):2384-91. Biochemistry. 2000. PMID: 10694407

3

A mammalian genetic system to screen for small molecules capable of disrupting protein-protein interactions.

Zhao HF, Kiyota T, Chowdhury S, Purisima E, Banville D, Konishi Y, Shen SH. Zhao HF, et al. Among authors: konishi y. Anal Chem. 2004 May 15;76(10):2922-7. doi: 10.1021/ac035396m. Anal Chem. 2004. PMID: 15144206

4

Design of a linker for trivalent thrombin inhibitors: interaction of the main chain of the linker with thrombin.

Szewczuk Z, Gibbs BF, Yue SY, Purisima E, Zdanov A, Cygler M, Konishi Y. Szewczuk Z, et al. Among authors: konishi y. Biochemistry. 1993 Apr 6;32(13):3396-404. doi: 10.1021/bi00064a025. Biochemistry. 1993. PMID: 8461303

5

Nonpolar interactions of thrombin S' subsites with its bivalent inhibitor: methyl scan of the inhibitor linker.

Slon-Usakiewicz JJ, Purisima E, Tsuda Y, Sulea T, Pedyczak A, Féthière J, Cygler M, Konishi Y. Slon-Usakiewicz JJ, et al. Among authors: konishi y. Biochemistry. 1997 Nov 4;36(44):13494-502. doi: 10.1021/bi970857h. Biochemistry. 1997. PMID: 9354617

6

Conformationally restricted thrombin inhibitors resistant to proteolytic digestion.

Szewczuk Z, Gibbs BF, Yue SY, Purisima EO, Konishi Y. Szewczuk Z, et al. Among authors: konishi y. Biochemistry. 1992 Sep 29;31(38):9132-40. doi: 10.1021/bi00153a004. Biochemistry. 1992. PMID: 1390700

With the aid of the model of the structure of the thrombin-hirudin fragment complex [Yue, S.-Y., DiMaio, J., Szewczuk, Z., Purisima, E. O., Ni, F., & Konishi, Y. (1992) Protein Eng. 5, 77-85], cyclic analogs of the hirudin fragment (hirudin55-65) were des …

With the aid of the model of the structure of the thrombin-hirudin fragment complex [Yue, S.-Y., DiMaio, J., Szewczuk, Z., Purisima, …

7

Synthesis of a homologous series of ketomethylene arginyl pseudodipeptides and application to low molecular weight hirudin-like thrombin inhibitors.

DiMaio J, Gibbs B, Lefebvre J, Konishi Y, Munn D, Yue SY, Hornberger W. DiMaio J, et al. Among authors: konishi y. J Med Chem. 1992 Sep 4;35(18):3331-41. doi: 10.1021/jm00096a004. J Med Chem. 1992. PMID: 1527782

8

Bifunctional thrombin inhibitors based on the sequence of hirudin45-65.

DiMaio J, Gibbs B, Munn D, Lefebvre J, Ni F, Konishi Y. DiMaio J, et al. Among authors: konishi y. J Biol Chem. 1990 Dec 15;265(35):21698-703. J Biol Chem. 1990. PMID: 2254323 Free article.

9

Calculation of relative binding free energies and configurational entropies: a structural and thermodynamic analysis of the nature of non-polar binding of thrombin inhibitors based on hirudin55-65.

Wang J, Szewczuk Z, Yue SY, Tsuda Y, Konishi Y, Purisima EO. Wang J, et al. Among authors: konishi y. J Mol Biol. 1995 Oct 27;253(3):473-92. doi: 10.1006/jmbi.1995.0567. J Mol Biol. 1995. PMID: 7473728

10

The specificity of the S1' subsite of cysteine proteases.

Ménard R, Carmona E, Plouffe C, Brömme D, Konishi Y, Lefebvre J, Storer AC. Ménard R, et al. Among authors: konishi y. FEBS Lett. 1993 Aug 9;328(1-2):107-10. doi: 10.1016/0014-5793(93)80975-z. FEBS Lett. 1993. PMID: 8344413 Free article.

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