Rothman RB - Search Results

1

Synthesis and biological evaluation of 14-alkoxymorphinans. 17. Highly delta opioid receptor selective 14-alkoxy-substituted indolo- and benzofuromorphinans.

Schütz J, Dersch CM, Horel R, Spetea M, Koch M, Meditz R, Greiner E, Rothman RB, Schmidhammer H. Schütz J, et al. Among authors: rothman rb. J Med Chem. 2002 Nov 21;45(24):5378-83. doi: 10.1021/jm020940p. J Med Chem. 2002. PMID: 12431065

2

Synthesis and biological activity of 8beta-substituted hydrocodone indole and hydromorphone indole derivatives.

Yu H, Prisinzano T, Dersch CM, Marcus J, Rothman RB, Jacobson AE, Rice KC. Yu H, et al. Among authors: rothman rb. Bioorg Med Chem Lett. 2002 Jan 21;12(2):165-8. doi: 10.1016/s0960-894x(01)00689-8. Bioorg Med Chem Lett. 2002. PMID: 11755345

3

Discovery of an opioid kappa receptor selective pure antagonist from a library of N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphans.

Thomas JB, Atkinson RN, Namdev N, Rothman RB, Gigstad KM, Fix SE, Mascarella SW, Burgess JP, Vinson NA, Xu H, Dersch CM, Cantrell BE, Zimmerman DM, Carroll FI. Thomas JB, et al. Among authors: rothman rb. J Med Chem. 2002 Aug 1;45(16):3524-30. doi: 10.1021/jm020084h. J Med Chem. 2002. PMID: 12139463

4

Synthesis, opioid receptor binding, and functional activity of 5'-substituted 17-cyclopropylmethylpyrido[2',3':6,7]morphinans.

Ananthan S, Kezar HS 3rd, Saini SK, Khare NK, Davis P, Dersch CM, Porreca F, Rothman RB. Ananthan S, et al. Among authors: rothman rb. Bioorg Med Chem Lett. 2003 Feb 10;13(3):529-32. doi: 10.1016/s0960-894x(02)00934-4. Bioorg Med Chem Lett. 2003. PMID: 12565965

5

Structure-activity relationship studies of highly selective inhibitors of the dopamine transporter: N-benzylpiperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine.

Greiner E, Prisinzano T, Johnson EM 2nd, Dersch CM, Marcus J, Partilla JS, Rothman RB, Jacobson AE, Rice KC. Greiner E, et al. Among authors: rothman rb. J Med Chem. 2003 Apr 10;46(8):1465-9. doi: 10.1021/jm020419v. J Med Chem. 2003. PMID: 12672246

6

Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a novel potent and selective opioid kappa receptor antagonist.

Thomas JB, Atkinson RN, Vinson NA, Catanzaro JL, Perretta CL, Fix SE, Mascarella SW, Rothman RB, Xu H, Dersch CM, Cantrell BE, Zimmerman DM, Carroll FI. Thomas JB, et al. Among authors: rothman rb. J Med Chem. 2003 Jul 3;46(14):3127-37. doi: 10.1021/jm030094y. J Med Chem. 2003. PMID: 12825951

7

Novel ligands for the opioid receptors: synthesis and structure-activity relationships among 5'-aryl and 5'-heteroaryl 17-cyclopropylmethyl-4,5 alpha-epoxypyrido[2',3':6,7]morphinans.

Ananthan S, Khare NK, Saini SK, Davis P, Dersch CM, Porreca F, Rothman RB. Ananthan S, et al. Among authors: rothman rb. Bioorg Med Chem. 2003 Sep 1;11(18):4143-54. doi: 10.1016/s0968-0896(03)00432-2. Bioorg Med Chem. 2003. PMID: 12927876

8

Diaryldimethylpiperazine ligands with mu- and delta-opioid receptor affinity: Synthesis of (+)-4-[(alphaR)-alpha-(4-allyl-(2S,5S)-dimethylpiperazin-1-yl)-(3-hydroxyphenyl)methyl]-N-ethyl-N-phenylbenzamide and (-)-4-[(alphaR)-alpha-(2S,5S)-dimethylpiperazin-1-yl)-(3-hydroxyphenyl)methyl]-N-ethyl-N-phenylbenzamide.

Kim IJ, Ullrich T, Janetka JW, Furness MS, Jacobson AE, Rothman RB, Dersch CM, Flippen-Anderson JL, George C, Rice KC. Kim IJ, et al. Among authors: rothman rb. Bioorg Med Chem. 2003 Nov 3;11(22):4761-8. doi: 10.1016/s0968-0896(03)00496-6. Bioorg Med Chem. 2003. PMID: 14556791

9

Importance of phenolic address groups in opioid kappa receptor selective antagonists.

Thomas JB, Fix SE, Rothman RB, Mascarella SW, Dersch CM, Cantrell BE, Zimmerman DM, Carroll FI. Thomas JB, et al. Among authors: rothman rb. J Med Chem. 2004 Feb 12;47(4):1070-3. doi: 10.1021/jm030467v. J Med Chem. 2004. PMID: 14761209

10

Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].

Ananthan S, Khare NK, Saini SK, Seitz LE, Bartlett JL, Davis P, Dersch CM, Porreca F, Rothman RB, Bilsky EJ. Ananthan S, et al. Among authors: rothman rb. J Med Chem. 2004 Mar 11;47(6):1400-12. doi: 10.1021/jm030311v. J Med Chem. 2004. PMID: 14998329

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