Chapman DF - Search Results

1

[3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization.

Anderson JJ, Rao SP, Rowe B, Giracello DR, Holtz G, Chapman DF, Tehrani L, Bradbury MJ, Cosford ND, Varney MA. Anderson JJ, et al. Among authors: chapman df. J Pharmacol Exp Ther. 2002 Dec;303(3):1044-51. doi: 10.1124/jpet.102.040618. J Pharmacol Exp Ther. 2002. PMID: 12438526

2

Metabotropic glutamate receptor 5 antagonist-induced stimulation of hypothalamic-pituitary-adrenal axis activity: interaction with serotonergic systems.

Bradbury MJ, Giracello DR, Chapman DF, Holtz G, Schaffhauser H, Rao SP, Varney MA, Anderson JJ. Bradbury MJ, et al. Among authors: chapman df. Neuropharmacology. 2003 Apr;44(5):562-72. doi: 10.1016/s0028-3908(03)00048-0. Neuropharmacology. 2003. PMID: 12668042

3

In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine).

Anderson JJ, Bradbury MJ, Giracello DR, Chapman DF, Holtz G, Roppe J, King C, Cosford ND, Varney MA. Anderson JJ, et al. Among authors: chapman df. Eur J Pharmacol. 2003 Jul 18;473(1):35-40. doi: 10.1016/s0014-2999(03)01935-6. Eur J Pharmacol. 2003. PMID: 12877935

4

2-(2-[3-(pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl) pyridine: a highly potent, orally active, metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.

Huang D, Poon SF, Chapman DF, Chung J, Cramer M, Reger TS, Roppe JR, Tehrani L, Cosford ND, Smith ND. Huang D, et al. Among authors: chapman df. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5473-6. doi: 10.1016/j.bmcl.2004.09.012. Bioorg Med Chem Lett. 2004. PMID: 15482906

5

3-[Substituted]-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitriles: identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonists.

Tehrani LR, Smith ND, Huang D, Poon SF, Roppe JR, Seiders TJ, Chapman DF, Chung J, Cramer M, Cosford ND. Tehrani LR, et al. Among authors: chapman df. Bioorg Med Chem Lett. 2005 Nov 15;15(22):5061-4. doi: 10.1016/j.bmcl.2005.07.062. Epub 2005 Sep 23. Bioorg Med Chem Lett. 2005. PMID: 16183275

6

3-[3-Fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)phenyl]-4-methylpyridine: a highly potent and orally bioavailable metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.

Poon SF, Eastman BW, Chapman DF, Chung J, Cramer M, Holtz G, Cosford ND, Smith ND. Poon SF, et al. Among authors: chapman df. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5477-80. doi: 10.1016/j.bmcl.2004.09.011. Bioorg Med Chem Lett. 2004. PMID: 15482907

7

Dehydroepiandrosterone sulfate is neuroprotective in a reversible spinal cord ischemia model: possible involvement of GABA(A) receptors.

Lapchak PA, Chapman DF, Nunez SY, Zivin JA. Lapchak PA, et al. Among authors: chapman df. Stroke. 2000 Aug;31(8):1953-6; discussion 1957. doi: 10.1161/01.str.31.8.1953. Stroke. 2000. PMID: 10926963

8

In vitro metabolism of indiplon and an assessment of its drug interaction potential.

Madan A, Fisher A, Jin L, Chapman D, Bozigian HP. Madan A, et al. Xenobiotica. 2007 Jul;37(7):736-52. doi: 10.1080/00498250701433054. Xenobiotica. 2007. PMID: 17620220

9

Comparison of TNK with wild-type tissue plasminogen activator in a rabbit embolic stroke model.

Chapman DF, Lyden P, Lapchak PA, Nunez S, Thibodeaux H, Zivin J. Chapman DF, et al. Stroke. 2001 Mar;32(3):748-52. doi: 10.1161/01.str.32.3.748. Stroke. 2001. PMID: 11239197

10

Metalloproteinase inhibition reduces thrombolytic (tissue plasminogen activator)-induced hemorrhage after thromboembolic stroke.

Lapchak PA, Chapman DF, Zivin JA. Lapchak PA, et al. Among authors: chapman df. Stroke. 2000 Dec;31(12):3034-40. doi: 10.1161/01.str.31.12.3034. Stroke. 2000. PMID: 11108768

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