Herdewijn P - Search Results

1

Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism.

Haouz A, Vanheusden V, Munier-Lehmann H, Froeyen M, Herdewijn P, Van Calenbergh S, Delarue M. Haouz A, et al. Among authors: herdewijn p. J Biol Chem. 2003 Feb 14;278(7):4963-71. doi: 10.1074/jbc.M209630200. Epub 2002 Nov 25. J Biol Chem. 2003. PMID: 12454011 Free article.

2

Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.

Vanheusden V, Munier-Lehmann H, Pochet S, Herdewijn P, Van Calenbergh S. Vanheusden V, et al. Among authors: herdewijn p. Bioorg Med Chem Lett. 2002 Oct 7;12(19):2695-8. doi: 10.1016/s0960-894x(02)00551-6. Bioorg Med Chem Lett. 2002. PMID: 12217356

3

Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.

Vanheusden V, Van Rompaey P, Munier-Lehmann H, Pochet S, Herdewijn P, Van Calenbergh S. Vanheusden V, et al. Among authors: herdewijn p. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3045-8. doi: 10.1016/s0960-894x(03)00643-7. Bioorg Med Chem Lett. 2003. PMID: 12941330

4

Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.

Vanheusden V, Munier-Lehmann H, Froeyen M, Busson R, Rozenski J, Herdewijn P, Van Calenbergh S. Vanheusden V, et al. Among authors: herdewijn p. J Med Chem. 2004 Dec 2;47(25):6187-94. doi: 10.1021/jm040847w. J Med Chem. 2004. PMID: 15566289

5

Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods.

Manallack DT, Pitt WR, Herdewijn P, Balzarini J, De Clercq E, Sanderson MR, Sohi M, Wien F, Munier-Lehmann H, Haouz A, Delarue M. Manallack DT, et al. Among authors: herdewijn p. J Enzyme Inhib Med Chem. 2002 Jun;17(3):167-74. doi: 10.1080/14756360290032949. J Enzyme Inhib Med Chem. 2002. PMID: 12443042 Free article.

6

3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.

Vanheusden V, Munier-Lehmann H, Froeyen M, Dugué L, Heyerick A, De Keukeleire D, Pochet S, Busson R, Herdewijn P, Van Calenbergh S. Vanheusden V, et al. Among authors: herdewijn p. J Med Chem. 2003 Aug 28;46(18):3811-21. doi: 10.1021/jm021108n. J Med Chem. 2003. PMID: 12930144 Free article.

7

Synthesis and evaluation of 6-aza-2'-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis.

Kögler M, Busson R, De Jonghe S, Rozenski J, Van Belle K, Louat T, Munier-Lehmann H, Herdewijn P. Kögler M, et al. Among authors: herdewijn p. Chem Biodivers. 2012 Mar;9(3):536-56. doi: 10.1002/cbdv.201100285. Chem Biodivers. 2012. PMID: 22422522

8

Synthesis and conformational analysis of 1-[2,4-dideoxy-4-C-hydroxymethyl-alpha-l-lyxopyranosyl]thymine.

Vanheusden V, Busson R, Herdewijn P, Van Calenbergh S. Vanheusden V, et al. Among authors: herdewijn p. J Org Chem. 2004 Jun 25;69(13):4446-53. doi: 10.1021/jo040130g. J Org Chem. 2004. PMID: 15202900

9

RNA as a target for drug design, the example of Tat-TAR interaction.

Froeyen M, Herdewijn P. Froeyen M, et al. Among authors: herdewijn p. Curr Top Med Chem. 2002 Oct;2(10):1123-45. doi: 10.2174/1568026023393200. Curr Top Med Chem. 2002. PMID: 12173971 Review.

10

5'-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N(6)-cyclopentyladenine: new adenosine A(1) receptor antagonists and inverse agonists.

Van Calenbergh S, Link A, Fujikawa S, de Ligt RA, Vanheusden V, Golisade A, Blaton NM, Rozenski J, IJzerman AP, Herdewijn P. Van Calenbergh S, et al. Among authors: herdewijn p. J Med Chem. 2002 Apr 25;45(9):1845-52. doi: 10.1021/jm0110439. J Med Chem. 2002. PMID: 11960496

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